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IL4/IL-4/Interleukin-4  Protein, Antibody, ELISA Kit, cDNA Clone

製品の説明: Active  
発現宿主: E. coli  
11846-HNAE-500
11846-HNAE-5
11846-HNAE-20
11846-HNAE-100
11846-HNAE-1
500 µg 
5 µg 
20 µg 
100 µg 
1 mg 
Add to Cart
  • Slide 1
発現宿主: E. coli  
51084-MNAE-5
51084-MNAE-20
51084-MNAE-100
5 µg 
20 µg 
100 µg 
Add to Cart
  • Slide 1
製品の説明: Active  
発現宿主: Baculovirus-Insect Cells  
51084-M08B-50
51084-M08B-20
51084-M08B-100
50 µg 
20 µg 
100 µg 
Add to Cart
  • Slide 1
発現宿主: E. coli  
70021-DNAE-5
70021-DNAE-20
70021-DNAE-100
5 µg 
20 µg 
100 µg 
Add to Cart
  • Slide 1

IL4/IL-4/Interleukin-4 Related Area

IL4/IL-4/Interleukin-4 関連製品

IL4/IL-4/Interleukin-4 サマリー & タンパク質情報

IL4/IL-4/Interleukin-4 背景

細胞内位置: Secreted.
疾患関連性: DISEASE: Ischemic stroke (ISCHSTR) [MIM:601367]: A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors. {ECO:0000269|PubMed:14681304}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
シーケンスの類似性: Belongs to the IL-4/IL-13 family. {ECO:0000305}.
General information above from UniProt

Interleukin-4, also known as IL4, is a secreted protein which belongs to the IL-4 / IL-13 family. Interleukin-4 / IL4 has many biological roles, including the stimulation of activated B-cell and T-cell proliferation. It enhances both secretion and cell surface expression of IgE and IgG1. Interleukin-4 / IL4 also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Interleukin-4 is essential for the switching of B cells to IgE antibody production and for the maturation of T helper (Th) cells toward the Th2 phenotype. It participates in at least several B-cell activation processes as well as of other cell types. However, studies show that double mutant (Q116D, Y119D) of the murine IL4 protein (QY), both glutamine 116 and tyrosine 119, which binds to the IL4 receptor alpha, completely inhibites in a dose-dependent manner the IL4-induced proliferation of lipopolysaccharide-stimulated murine splenic B-cells, of the murine T cell line CTLL-2, and of the murine pre-B-cell line BA/F3. QY also inhibited the IL4-stimulated up-regulation of CD23 expression by lipopolysaccharide-stimulated murine splenic B-cells and abolished tyrosine phosphorylation of the transcription factor Stat6 and the tyrosine kinase Jak3 in IL4-stimulated BA/F3 cells.

Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

IL4/IL-4/Interleukin-4 代替名

BSF-1,Interleukin-4,BSF-1, []
BSF1,IL-4,BCGF1,BSF-1,BCGF-1, [homo-sapiens]
BCGF1,BCGF-1,BSF1,IL4,IL-4,MGC79402, [human]
Il-4,Il4,RP23-188H3.4, [mouse]
Il-4,BSF-1, [mus-musculus]

IL4/IL-4/Interleukin-4 関連研究

  • Grunewald SM. et al., 1998, J Immunol. 160 (8): 4004-9.
  • Susanne M. et al, 1997, THE JOURNAL OF BIOLOGICAL CHEMISTRY. 272 (3): 1480-3.
  • Nishikubo K. et al., 2003, Gene Ther. 10 (26): 2119-25.
  • 注意:すべての製品は、"研究目的のみに使用するものであり、診断または治療目的に使用するものではありません"