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IL-36B / IL-1F8 抗体, ウサギポリクローナル抗体, Antigen Affinity Purified

データシートレビュー関連製品プロトコル
Mouse IL36B 抗体製品情報
免疫原:Recombinant Mouse IL-36B / IL-1F8 protein (Catalog#51071-MNAE)
Clone ID:
Ig タイプ:Rabbit IgG
濃度:
エンドトキシン:
製剤:0.2 μm filtered solution in PBS with 5% trehalose
調製:Produced in rabbits immunized with purified, recombinant Mouse IL-36B / IL-1F8 (rM IL-36B / IL-1F8; Catalog#51071-MNAE; Q9D6Z6; Met1-Lys183). IL-36B / IL-1F8 specific IgG was purified by Mouse IL-36B / IL-1F8 affinity chromatography.
Mouse IL36B 抗体使用ガイド
特異度:Mouse IL-36B / IL-1F8
アプリケーション:WB, ELISA, IHC-P

WB: 5-10 μg/mL

ELISA: 0.1-0.2 μg/mL

This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Mouse IL-36B / IL-1F8. The detection limit for Mouse IL-36B / IL-1F8 is approximately 0.039 ng/well.

IHC-P: 0.1-2 μg/mL

保存:This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Mouse IL36B Antibody WB Application Image
Mouse IL36B Antibody IHC Application Image
IL-36B / IL-1F8 Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry
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Caption:
Immunochemical staining of mouse IL1F8 in mouse intestine with rabbit polyclonal antibody (1 µg/mL, formalin-fixed paraffin embedded sections). The left panel: tissue incubated with primary antibody; The right panel: tissue incubated with the mixture of primary antibody and antigen (recombinant protein).
IL-36B / IL-1F8 Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry
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Caption:
Immunochemical staining of mouse IL1F8 in mouse stomach with rabbit polyclonal antibody (1 µg/mL, formalin-fixed paraffin embedded sections).
Other IL36B Antibody Products
IL36B/IL1F8 背景

Interleukin-1 family member 8(IL1F8) also known as IL36B, is a member of the interleukin 1(IL-1) cytokine family. IL1F8 may contains a 12-stranded beta-trefoil structure. Until recently, the IL-1 family of cytokines includ four members, with three having pro-inflammatory effects such as IL1F8 and the fourth member being an IL-1 receptor antagonist (IL-1Ra). IL-1 family members exert their effects through binding to receptors that belong to the IL-1 receptor (IL-1R) family. IL1F8 exerts proinflammatory effects in primary human joint cells. Joint and serum IL-1F8 protein levels did not correlate with inflammation, but they were high in some human serum samples tested, including samples from patients with rheumatoid arthritis. IL1F8 also activated NK-κB.

Mouse IL36B/IL1F8 参考文献
  • Magne D, et al. (2006) The new IL-1 family member IL-1F8 stimulates production of inflammatory mediators by synovial fibroblasts and articular chondrocytes. Arthritis Research & Therapy. 8: R80.
  • Smith DE, et al. (2000) The new IL-1 family member IL-1F8 stimulates production of inflammatory mediators by synovial fibroblasts and articular chondrocytes. The Journal of Biological Chemistry. 275: 1169-75.
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    注意:すべての製品は、"研究目的のみに使用するものであり、診断または治療目的に使用するものではありません"