IL25 (タンパク質 | 抗体 | cDNA クローン | ELISA キット)

All IL25 reagents are produced in house and quality controlled, including 3 IL25 Antibody, 40 IL25 Gene, 3 IL25 Lysate, 3 IL25 Protein, 2 IL25 qPCR. All IL25 reagents are ready to use.

IL25 Protein (3)

IL25 Antibody (3)

IL25 cDNA Clone (40)

In expression vector

NM_080729.2

クローニングベクター cDNA 製品

In lentiviral vector

NM_001192007.1

クローニングベクター cDNA 製品

In lentiviral vector

XM_005623236.1

クローニングベクター cDNA 製品

In lentiviral vector

IL25 Lysate (3)

IL25 の背景知識

Interleukin-25 (IL-25) is a cytokine that shares sequence similarity with interleukin 17. This cytokine can induce NF-kappaB activation, and stimulate the production of interleukin 8. Both this cytokine and interleukin 17B are ligands for the cytokine receptor IL17BR. IL-25 is a member of the IL-17 family of cytokines. However, unlike the other members of this family, IL-25 promotes T helper (Th) 2 responses. IL-25 also regulates the development of autoimmune inflammation mediated by IL-17–producing T cells. IL-25 and IL-17, being members of the same cytokine family, play opposing roles in the pathogenesis of organ-specific autoimmunity. IL-25 promotes cell expansion and Th2 cytokine production when Th2 central memory cells are stimulated with thymic stromal lymphopoietin (TSLP)–activated dendritic cells (DCs), homeostatic cytokines, or T cell receptor for antigen triggering. Elevated expression of IL-25 and IL-25R transcripts was observed in asthmatic lung tissues and atopic dermatitis skin lesions, linking their possible roles with exacerbated allergic disorders. A plausible explanation that IL-25 produced by innate effector eosinophils and basophils may augment the allergic inflammation by enhancing the maintenance and functions of adaptive Th2 memory cells had been provided.

IL25 の参考文献

  • Rickel EA, et al.. (2008) Identification of functional roles for both IL-17RB and IL-17RA in mediating IL-25-induced activities. J Immunol. 181(6): 4299-310.
  • Tamachi T, et al.. (2006) IL-25 enhances allergic airway inflammation by amplifying a TH2 cell-dependent pathway in mice. J Allergy Clin Immunol. 118(3): 606-14.
  • Kleinschek MA, et al.. (2007) IL-25 regulates Th17 function in autoimmune inflammation. J Exp Med. 204(1): 161-70.