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IL-17E/IL-25  Protein, Antibody, ELISA Kit, cDNA Clone

発現宿主: Human Cells  
10096-H01H-50
10096-H01H-20
50 µg 
20 µg 
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  • Slide 1
製品の説明: Active  
発現宿主: Human Cells  
50138-M07H-50
50138-M07H-5
50138-M07H-20
50 µg 
5 µg 
20 µg 
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  • Slide 1
製品の説明: Active  
発現宿主: Human Cells  
80194-R01H-50
80194-R01H-20
50 µg 
20 µg 
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  • Slide 1

IL-17E/IL-25 Related Area

IL-17E/IL-25 関連経路

IL-17E/IL-25 サマリー & タンパク質情報

IL-17E/IL-25 背景

遺伝子の概要: The protein encoded by IL-25 gene is a cytokine that shares sequence similarity with interleukin 17. This cytokine can induce NF-kappaB activation, and stimulate the production of interleukin 8. Both this cytokine and interleukin 17B are ligands for the cytokine receptor IL17BR. Studies of a similar gene in mice suggest that this cytokine may be a pro-inflammatory cytokine favoring the Th2-type immune response. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]
General information above from NCBI
細胞内位置: Secreted.
組織特異性: Expressed at low levels in several tissues, including brain, kidney, lung, prostate, testis, spinal cord, adrenal gland, and trachea.
シーケンスの類似性: Belongs to the IL-17 family. {ECO:0000305}.
General information above from UniProt

Interleukin-25 (IL-25) is a cytokine that shares sequence similarity with interleukin 17. This cytokine can induce NF-kappaB activation, and stimulate the production of interleukin 8. Both this cytokine and interleukin 17B are ligands for the cytokine receptor IL17BR. IL-25 is a member of the IL-17 family of cytokines. However, unlike the other members of this family, IL-25 promotes T helper (Th) 2 responses. IL-25 also regulates the development of autoimmune inflammation mediated by IL-17–producing T cells. IL-25 and IL-17, being members of the same cytokine family, play opposing roles in the pathogenesis of organ-specific autoimmunity. IL-25 promotes cell expansion and Th2 cytokine production when Th2 central memory cells are stimulated with thymic stromal lymphopoietin (TSLP)–activated dendritic cells (DCs), homeostatic cytokines, or T cell receptor for antigen triggering. Elevated expression of IL-25 and IL-25R transcripts was observed in asthmatic lung tissues and atopic dermatitis skin lesions, linking their possible roles with exacerbated allergic disorders. A plausible explanation that IL-25 produced by innate effector eosinophils and basophils may augment the allergic inflammation by enhancing the maintenance and functions of adaptive Th2 memory cells had been provided.

IL-17E/IL-25 代替名

IL-17E/IL-25 関連研究

  • Rickel EA, et al.. (2008) Identification of functional roles for both IL-17RB and IL-17RA in mediating IL-25-induced activities. J Immunol. 181(6): 4299-310.
  • Tamachi T, et al.. (2006) IL-25 enhances allergic airway inflammation by amplifying a TH2 cell-dependent pathway in mice. J Allergy Clin Immunol. 118(3): 606-14.
  • Kleinschek MA, et al.. (2007) IL-25 regulates Th17 function in autoimmune inflammation. J Exp Med. 204(1): 161-70.
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