IL-15 (タンパク質 | 抗体 | cDNA クローン | ELISA キット)

All IL-15 reagents are produced in house and quality controlled, including 6 IL-15 Antibody, 1 IL-15 ELISA, 52 IL-15 Gene, 3 IL-15 Protein, 3 IL-15 qPCR. All IL-15 reagents are ready to use.

IL-15 Protein (3)

IL-15 Antibody (6)

IL-15 ELISA キット(すぐに使用できます)& ELISA抗体ペアセット(すぐに使用できません)(1)

IL-15 cDNA Clone (52)

NM_172174.2

クローニングベクター cDNA 製品

In lentiviral vector

NM_008357.1

クローニングベクター cDNA 製品

In lentiviral vector

NM_013129.2

クローニングベクター cDNA 製品

In lentiviral vector

NM_001044731.1

クローニングベクター cDNA 製品

In lentiviral vector

IL-15 の背景知識

The protein encoded by IL15 gene is a cytokine that regulates T and natural killer cell activation and proliferation. This cytokine and interleukine 2 share many biological activities. They are found to bind common hematopoietin receptor subunits, and may compete for the same receptor, and thus negatively regulate each other's activity. The number of CD8+ memory cells is shown to be controlled by a balance between this cytokine and IL2. This cytokine induces the activation of JAK kinases, as well as the phosphorylation and activation of transcription activators STAT3, STAT5, and STAT6. Studies of the mouse counterpart suggested that this cytokine may increase the expression of apoptosis inhibitor BCL2L1/BCL-x(L), possibly through the transcription activation activity of STAT6, and thus prevent apoptosis. Alternatively spliced transcript variants of this gene have been reported.

IL-15 の参考文献

  • Mongini PKA, Gupta R, Boyle E, et al. TLR-9 and IL-15 synergy promotes the in vitro clonal expansion of chronic lymphocytic leukemia B cells. Journal of immunology (Baltimore, Md : 1950). 2015;195(3):901-923.