IL11 (タンパク質 | 抗体 | cDNA クローン | ELISA キット)

All IL11 reagents are produced in house and quality controlled, including 2 IL11 Antibody, 40 IL11 Gene, 2 IL11 Protein, 3 IL11 qPCR. All IL11 reagents are ready to use.

IL11 Protein (2)

IL11 Antibody (2)

IL11 cDNA Clone (40)

BC012506

クローニングベクター cDNA 製品

In lentiviral vector

NM_008350.2

クローニングベクター cDNA 製品

In lentiviral vector

NM_133519.3

クローニングベクター cDNA 製品

In lentiviral vector

In expression vector

IL11 の背景知識

IL11 is a multifunctional cytokine first isolated in 199 from bone marrow-derived stromal cells. It is a key regulator of multiple events in hematopoiesis, most notably the stimulation of megakaryocyte maturation. IL11 is also known under the names adipogenesis inhibitory factor (AGIF) and oprelvekin. IL11 can improve platelet recovery after chemotherapy-induced thrombocytopenia, induce acute phase proteins, modulate antigen-antibody responses, participate in the regulation of bone cell proliferation and differentiation and could be use as a therapeutic for osteoporosis. IL11 stimulates the growth of certain lymphocytes and, in the murine model, stimulates an increase in the cortical thickness and strength of long bones. As a signaling molecule, IL11 has a variety of functions associated with its receptor interleukin 11 receptor alpha; such functions include placentation and to some extent of decidualization.

IL11 の参考文献

  • McKinley D. et al., 1992, Genomics. 13 (3): 814-9.
  • Paul SR. et al., 1990, Proc Natl Acad Sci. 87 (19): 7512-6.
  • Kawashima I. et al., 1991, FEBS Lett. 283 (2): 199-202.