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IL-11 / interleukin 11  Protein, Antibody, ELISA Kit, cDNA Clone

発現宿主: E. coli  
12225-HNCE-50
12225-HNCE-5
12225-HNCE-20
12225-HNCE-10
50 µg 
5 µg 
20 µg 
10 µg 
Add to Cart
  • Slide 1
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発現宿主: E. coli  
50117-MNCE-50
50117-MNCE-5
50117-MNCE-100
50117-MNCE-10
50 µg 
5 µg 
100 µg 
10 µg 
Add to Cart
  • Slide 1

IL-11 / interleukin 11 Related Area

IL-11 / interleukin 11 関連経路

    IL-11 / interleukin 11 関連製品

    IL-11 / interleukin 11 サマリー & タンパク質情報

    IL-11 / interleukin 11 背景

    サブユニット構造: Interacts with IL6ST and either IL11RA1 or IL11RA2, giving rise to a multimeric signaling complex. {ECO:0000269|PubMed:12919066, ECO:0000305|PubMed:12919066}.
    細胞内位置: Secreted {ECO:0000269|PubMed:1828438, ECO:0000269|PubMed:2145578}.
    シーケンスの類似性: Belongs to the IL-6 superfamily. {ECO:0000305}.
    General information above from UniProt

    IL11 is a multifunctional cytokine first isolated in 1990 from bone marrow-derived stromal cells. It is a key regulator of multiple events in hematopoiesis, most notably the stimulation of megakaryocyte maturation. IL11 is also known under the names adipogenesis inhibitory factor (AGIF) and oprelvekin. IL11 can improve platelet recovery after chemotherapy-induced thrombocytopenia, induce acute phase proteins, modulate antigen-antibody responses, participate in the regulation of bone cell proliferation and differentiation and could be use as a therapeutic for osteoporosis. IL11 stimulates the growth of certain lymphocytes and, in the murine model, stimulates an increase in the cortical thickness and strength of long bones. As a signaling molecule, IL11 has a variety of functions associated with its receptor interleukin 11 receptor alpha; such functions include placentation and to some extent of decidualization.

    IL-11 / interleukin 11 代替名

    AGIF,IL-11, [homo-sapiens]
    interleukin 11,IL11,AGIF,IL-11,adipogenesis inhibitory factor,oprelvekin, [human]
    interleukin 11,Il11,IL-11, [mouse]
    IL-11, [mus-musculus]

    IL-11 / interleukin 11 関連研究

  • McKinley D. et al., 1992, Genomics. 13 (3): 814-9.
  • Paul SR. et al., 1990, Proc Natl Acad Sci. 87 (19): 7512-6.
  • Kawashima I. et al., 1991, FEBS Lett. 283 (2): 199-202.
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