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IL10/IL-10/Interleukin-10  Protein, Antibody, ELISA Kit, cDNA Clone

発現宿主: Human Cells  
10947-H07H-5
10947-H07H-20
10947-H07H-100
5 µg 
20 µg 
100 µg 
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  • Slide 1
発現宿主: E. coli  
10947-HNAE-500
10947-HNAE-5
10947-HNAE-20
10947-HNAE-100
10947-HNAE-1
500 µg 
5 µg 
20 µg 
100 µg 
1 mg 
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発現宿主: E. coli  
80082-RNAE-20
80082-RNAE-10
20 µg 
10 µg 
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  • Slide 1
発現宿主: E. coli  
62000-WNAE-5
62000-WNAE-20
62000-WNAE-100
5 µg 
20 µg 
100 µg 
Add to Cart
  • Slide 1

IL10/IL-10/Interleukin-10 Related Area

IL10/IL-10/Interleukin-10 関連経路

IL10/IL-10/Interleukin-10 関連製品

IL10/IL-10/Interleukin-10 サマリー & タンパク質情報

IL10/IL-10/Interleukin-10 背景

遺伝子の概要: The IL-10 protein encoded by this IL10 gene is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This IL-10 cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This IL-10 cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract. Mutations in this IL10 gene are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis.[provided by RefSeq, May 2011]
General information above from NCBI
サブユニット構造: Homodimer. {ECO:0000269|PubMed:11485736, ECO:0000269|PubMed:15837194}.
細胞内位置: Secreted.
組織特異性: Produced by a variety of cell lines, including T-cells, macrophages, mast cells and other cell types.
シーケンスの類似性: Belongs to the IL-10 family. {ECO:0000305}.
General information above from UniProt

IL-10 is a anti-inflammatory cytokine which belongs to the IL-10 family. It is produced by a variety of cell lines, including T-cells, macrophages, mast cells and other cell types, while it is produced primarily by monocytes and to a lesser extent by lymphocytes. IL-10 is mainly expressed in monocytes and Type 2 T helper cells (TH2), mast cells, CD4+CD25+Foxp3+ regulatory T cells, and also in a certain subset of activated T cells and B cells. IL-10 has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. IL-10 can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract. The importance of interleukin 10 for counteracting excessive immunity in the human body is revealed by the fact that patients with Crohn's disease react favorably towards treatment with bacteria producing recombinant IL-10. IL-10 inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and by helper T-cells. It also displays a potent ability to suppress the antigen-presentation capacity of antigen presenting cells. However, it is also stimulatory towards certain T cells and mast cells and stimulates B cell maturation and antibody production.

Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

IL10/IL-10/Interleukin-10 代替名

Interleukin-10,GVHDS, []
CSIF,TGIF,GVHDS,IL-10,IL10A, [homo-sapiens]
IL10,MGC126451,CSIF,IL-10,IL10A,MGC126450,RP11-262N9.1,TGIF, [human]
CSIF,Il10,Il-10,AL513351.1, [mouse]
CSIF,Il-10, [mus-musculus]

IL10/IL-10/Interleukin-10 関連研究

  • Arimoto T, et al. (2007) Interleukin-10 protects against inflammation-mediated degeneration of dopaminergic neurons in substantia nigra. Neurobiol Aging. 28(6):894-906.
  • Han X, et al. (2010) Effect of cobalt protoporphyrin on hyperexpression of heme oxygenase-1 and secretion of IL-10 in rat bone marrow mesenchymal stem cells. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 18(5):1297-301.
  • Cui QQ, et al. (2011) Expression of RhoA in the lung tissue of acute lung injury rats and the influence of RhoA on the expression of IL-8 and IL-10. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 77(7): 1436-41.
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