IL-10 (タンパク質 | 抗体 | cDNA クローン | ELISA キット)

All IL-10 reagents are produced in house and quality controlled, including 9 IL-10 Antibody, 2 IL-10 ELISA, 52 IL-10 Gene, 1 IL-10 Lysate, 6 IL-10 Protein, 3 IL-10 qPCR. All IL-10 reagents are ready to use.

IL-10 Protein (6)

IL-10 Antibody (9)

IL-10 ELISA キット(すぐに使用できます)& ELISA抗体ペアセット(すぐに使用できません)(2)

IL-10 cDNA Clone (52)

NM_000572.2

クローニングベクター cDNA 製品

In lentiviral vector

NM_010548.1

クローニングベクター cDNA 製品

In lentiviral vector

NM_012854.2

クローニングベクター cDNA 製品

In lentiviral vector

NM_001003077.1

クローニングベクター cDNA 製品

In lentiviral vector

IL-10 Lysate (1)

IL-10 の背景知識

IL-1 is a anti-inflammatory cytokine which belongs to the IL-1 family. It is produced by a variety of cell lines, including T-cells, macrophages, mast cells and other cell types, while it is produced primarily by monocytes and to a lesser extent by lymphocytes. IL-1 is mainly expressed in monocytes and Type 2 T helper cells (TH2), mast cells, CD4+CD25+Foxp3+ regulatory T cells, and also in a certain subset of activated T cells and B cells. IL-1 has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. IL-1 can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract. The importance of interleukin 1 for counteracting excessive immunity in the human body is revealed by the fact that patients with Crohn's disease react favorably towards treatment with bacteria producing recombinant IL-1. IL-1 inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and by helper T-cells. It also displays a potent ability to suppress the antigen-presentation capacity of antigen presenting cells. However, it is also stimulatory towards certain T cells and mast cells and stimulates B cell maturation and antibody production.

IL-10 の参考文献

  • Arimoto T, et al. (2007) Interleukin-10 protects against inflammation-mediated degeneration of dopaminergic neurons in substantia nigra. Neurobiol Aging. 28(6):894-906.
  • Han X, et al. (2010) Effect of cobalt protoporphyrin on hyperexpression of heme oxygenase-1 and secretion of IL-10 in rat bone marrow mesenchymal stem cells. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 18(5):1297-301.
  • Cui QQ, et al. (2011) Expression of RhoA in the lung tissue of acute lung injury rats and the influence of RhoA on the expression of IL-8 and IL-10. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 77(7): 1436-41.