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IL1B/IL-1B/IL-1 beta  Protein, Antibody, ELISA Kit, cDNA Clone

製品の説明: Active  
発現宿主: E. coli  
10139-HNAE-500
10139-HNAE-5
10139-HNAE-20
10139-HNAE-100
10139-HNAE-1
500 µg 
5 µg 
20 µg 
100 µg 
1 mg 
Add to Cart
  • Slide 1
製品の説明: Active  
発現宿主: E. coli  
10139-H07E-50
10139-H07E-20
50 µg 
20 µg 
Add to Cart
  • Slide 1
製品の説明: Active  
発現宿主: E. coli  
50101-MNAE-500
50101-MNAE-5
50101-MNAE-20
50101-MNAE-100
50101-MNAE-1
500 µg 
5 µg 
20 µg 
100 µg 
1 mg 
Add to Cart
  • Slide 1
発現宿主: E. coli  
80023-R07E-50
80023-R07E-20
50 µg 
20 µg 
Add to Cart
  • Slide 1
製品の説明: Active  
発現宿主: E. coli  
80023-RNAE-5
80023-RNAE-20
80023-RNAE-100
5 µg 
20 µg 
100 µg 
Add to Cart
  • Slide 1
製品の説明: Active  
発現宿主: E. coli  
90010-CNAE-500
90010-CNAE-5
90010-CNAE-20
90010-CNAE-100
90010-CNAE-1
500 µg 
5 µg 
20 µg 
100 µg 
1 mg 
Add to Cart
  • Slide 1
製品の説明: Active  
発現宿主: E. coli  
70018-DNAE-5
70018-DNAE-20
70018-DNAE-100
5 µg 
20 µg 
100 µg 
Add to Cart
  • Slide 1
発現宿主: E. coli  
65004-TNAE-5
65004-TNAE-20
65004-TNAE-100
5 µg 
20 µg 
100 µg 
Add to Cart
  • Slide 1
発現宿主: E. coli  
62003-WNAE-5
62003-WNAE-20
62003-WNAE-10
5 µg 
20 µg 
10 µg 
Add to Cart
  • Slide 1
発現宿主: E. coli  
67002-UNAE-5
67002-UNAE-20
67002-UNAE-10
5 µg 
20 µg 
10 µg 
Add to Cart
  • Slide 1

IL1B/IL-1B/IL-1 beta Related Area

IL1B/IL-1B/IL-1 beta 関連経路

IL1B/IL-1B/IL-1 beta 関連製品

IL1B/IL-1B/IL-1 beta サマリー & タンパク質情報

IL1B/IL-1B/IL-1 beta 背景

遺伝子の概要: The protein encoded by IL1B gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. IL1B gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2.
General information above from NCBI
サブユニット構造: Monomer. Interacts with MEFV. {ECO:0000269|PubMed:17431422, ECO:0000269|PubMed:20802483}.
ドメイン: The similarity among the IL-1 precursors suggests that the amino ends of these proteins serve some as yet undefined function.
細胞内位置: Secreted. Note=The lack of a specific hydrophobic segment in the precursor sequence suggests that IL-1 is released by damaged cells or is secreted by a mechanism differing from that used for other secretory proteins.
シーケンスの類似性: Belongs to the IL-1 family. {ECO:0000305}.
General information above from UniProt

Interleukin-1 beta (IL1 beta or IL1B) also known as catabolin, is a member of the interleukin 1 cytokine family. IL1 is a pleiotropic cytokine. It is involved in the inflammatory response, cell growth, and tissue repair in the cortex. The IL1 superfamily consists of three members, IL1A (IL1 alpha), IL1B (IL1 beta), and IL1 receptor antagonist (IL1Ra). In clinical, it has been reported that Interleukin (IL)-1 may influence Th1 / Th2 immune responsiveness and has been implicated in the establishment of successful pregnancy. Proinflammatory interleukin (IL)-1 gene polymorphisms associated with high levels of IL-1beta activity increase the risk for hypochlorhydria and distal gastric carcinoma. IL1B polymorphisms may be involved in susceptibility to SSc. Moreover, the IL2-384-G allele may be a marker for the limited phenotype of systemic sclerosis (SSc).

Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

IL1B/IL-1B/IL-1 beta 代替名

IL-1B,Il-1b, []
IL-1,IL1F2,IL1-BETA, [homo-sapiens]
IL-1,IL-1 beta,IL1B,IL1-BETA,IL1F2, [human]
Il-1b,IL-1beta, [mus-musculus]

IL1B/IL-1B/IL-1 beta 関連研究

  • Kim SH, et al. (2008) Association of -31TC and -511 CT polymorphisms in the interleukin 1 beta (IL1B) promoter in Korean keratoconus patients. Mol Vis. 14:2109-16.
  • Wang ZC, et al. (2002) T helper 1-type immunity to trophoblast antigens in women with a history of recurrent pregnancy loss is associated with polymorphism of the IL1B promoter region. Genes Immun. 3(1): 38-42.
  • Mattuzzi S, et al. (2007) Association of polymorphisms in the IL1B and IL2 genes with susceptibility and severity of systemic sclerosis. J Rheumatol. 34(5): 997-1004.
  • 注意:すべての製品は、"研究目的のみに使用するものであり、診断または治療目的に使用するものではありません"