IL-1 alpha / IL1A (タンパク質 | 抗体 | cDNA クローン | ELISA キット)

All IL-1 alpha / IL1A reagents are produced in house and quality controlled, including 10 IL-1 alpha / IL1A Antibody, 2 IL-1 alpha / IL1A ELISA, 65 IL-1 alpha / IL1A Gene, 1 IL-1 alpha / IL1A IP Kit, 1 IL-1 alpha / IL1A Lysate, 2 IL-1 alpha / IL1A Protein, 3 IL-1 alpha / IL1A qPCR. All IL-1 alpha / IL1A reagents are ready to use.

All IL-1 alpha / IL1A Reagents

IL-1 alpha / IL1A Protein (2)

IL-1 alpha / IL1A Antibody (10)

IL-1 alpha / IL1A ELISA キット(すぐに使用できます)& ELISA抗体ペアセット(すぐに使用できません)(2)

IL-1 alpha / IL1A cDNA Clone (65)

NM_000575.3

クローニングベクター cDNA 製品

In lentiviral vector

NM_010554.4

クローニングベクター cDNA 製品

In lentiviral vector

NM_017019.1

クローニングベクター cDNA 製品

In lentiviral vector

NM_001003157.2

クローニングベクター cDNA 製品

In lentiviral vector

NM_001042757.1

クローニングベクター cDNA 製品

In lentiviral vector

IL-1 alpha / IL1A Lysate (1)

IL-1 alpha / IL1A の背景知識

IL-1 alpha is a member of the interleukin 1 cytokine family. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proliferation, differentiation and cell survival/apoptosis but are also involved in several pathophysiological processes including viral infections and autoimmune diseases. Cytokines are synthesized under various stimuli by a variety of cells of both the innate (monocytes, macrophages, dendritic cells) and adaptive (T- and B-cells) immune systems. Cytokines can be classified into two groups: pro- and anti-inflammatory. Pro-inflammatory cytokines, including IFNgamma, IL-1, IL-6 and TNF-alpha, are predominantly derived from the innate immune cells and Th1 cells. Anti-inflammatory cytokines, including IL-1, IL-4, IL-13 and IL-5, are synthesized from Th2 immune cells. IL-1 alpha is a pleiotropic cytokine involved in various immune responses, inflammatory processes, and hematopoiesis. It is produced by monocytes and macrophages as a proprotein, which is proteolytically processed and released in response to cell injury, and thus induces apoptosis. IL-1 alpha stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity.

IL-1 alpha / IL1A の参考文献

  • Nicklin MJ,et al. (1994) A physical map of the region encompassing the human interleukin-1 alpha, interleukin-1 beta, and interleukin-1 receptor antagonist genes. Genomics. 19(2):382-4.
  • March CJ, et al. (1985) Cloning, sequence and expression of two distinct human interleukin-1 complementary DNAs. Nature. 315(6021):641-7.
  • Bankers-Fulbright JL, et al. (1996) Interleukin-1 signal transduction. Life Sci. 59(2):61-83.
  • Dinarello CA, et al. (1997) Induction of interleukin-1 and interleukin-1 receptor antagonist. Semin Oncol. 24 (3 Suppl 9):S9-81-S9-93.