IP6K1 / IHPK1 Protein, Human, Recombinant (His & GST Tag)

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IP6K1 / IHPK1 Protein, Human, Recombinant (His & GST Tag): 製品情報

純度
> 85 % as determined by SDS-PAGE
内毒素
< 1.0 EU per μg of the protein as determined by the LAL method
活性
Kinase activity untested
タンパク質の構築
A DNA sequence encoding the human IHPK1 (Q92551-1) (Met1-Gln441) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.
NCBI Reference No.
発現ホスト
Baculovirus-Insect Cells
Human
予測N末端
Met
分子量
The recombinant human IHPK1 /GST chimera consists of 678 amino acids and has a calculated molecular mass of 78 kDa. The recombinant protein migrates approximately 88 kDa band in SDS-PAGE under reducing conditions.
バッファー
Supplied as sterile 20mM Tris, 500mM NaCl, pH 8.0, 10% gly
1. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
2. Please contact us for any concerns or special requirements.
Please refer to the specific buffer information in the hard copy of CoA.
配送
Kinases are highly recommended to be shipped at frozen temperature with blue ice or dry ice.
Shipment made at ambient temperature may seriously affect the activity of the ordered products.
安定性 & 保存条件
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃
Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
再構成
A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

IP6K1 / IHPK1 Protein, Human, Recombinant (His & GST Tag): 画像

IP6K1 / IHPK1 Protein, Human, Recombinant (His & GST Tag): 別名

IHPK1 Protein, Human; PiUS Protein, Human

IP6K1 / IHPK1 背景情報

IHPK1 is a inositol hexaphosphate kinase (IHPK) protein which belongs to the inositol phosphokinase (IPK) family. IHPK proteins are likely responsible for the conversion of inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). IHPK1 may also convert 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4 and affect the growth suppressive and apoptotic activities of interferon-beta in some ovarian cancers. During cell death, IHPK1 activity is enhanced, and intracellular InsP7 level is augmented. The distribution of IHPK1 or another predisposing gene affected by position effect of translocation may explain the T2DM phenotype at least in this family.
完全な名称
inositol hexakisphosphate kinase 1
参考文献
  • Strausberg RL, et al. (2003) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci. 99(26):16899-903.
  • Saiardi A, et al. (2001) Identification and characterization of a novel inositol hexakisphosphate kinase. J Biol Chem. 276(42):39179-85.
  • Kamimura J, et al. (2004) The IHPK1 gene is disrupted at the 3p21.31 breakpoint of t(3;9) in a family with type 2 diabetes mellitus. J Hum Genet. 49(7):360-5.
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