IFN-beta (タンパク質 | 抗体 | cDNA クローン | ELISA キット)

All IFN-beta reagents are produced in house and quality controlled, including 6 IFN-beta Antibody, 52 IFN-beta Gene, 5 IFN-beta Lysate, 5 IFN-beta Protein, 3 IFN-beta qPCR. All IFN-beta reagents are ready to use.

IFN-beta Protein (5)

IFN-beta Antibody (6)

IFN-beta cDNA Clone (52)

NM_002176.2

クローニングベクター cDNA 製品

In lentiviral vector

NM_010510.1

クローニングベクター cDNA 製品

In lentiviral vector

NM_019127.1

クローニングベクター cDNA 製品

In lentiviral vector

NM_001135795.1

クローニングベクター cDNA 製品

In lentiviral vector

IFN-beta Lysate (5)

IFN-beta の背景知識

Interferons (IFNs) are natural glycoproteins belonging to the cytokine superfamily, and are produced by the cells of the immune system of most vertebrates in response to challenges by foreign agents such as viruses, parasites and tumor cells. Interferon-beta (IFN beta) is an extra-cellular protein mediator of host defense and homeostasis. IFN beta has well-established direct antiviral, antiproliferative and immunomodulatory properties. Recombinant IFN beta is approved for the treatment of relapsing-remitting multiple sclerosis. The recombinant IFN beta protein has the theoretical potential to either treat or cause autoimmune neuromuscular disorders by altering the complicated and delicate balances within the immune system networks. It is the most widely prescribed disease-modifying therapy for multiple sclerosis (MS). Large-scale clinical trials have established the clinical efficacy of IFN beta in reducing relapses and slowing disease progression in relapsing-remitting MS. IFN beta therapy was shown to be comparably beneficial for opticospinal MS (OSMS) and conventional MS in Japanese. IFN beta is effective in reducing relapses in secondary progressive MS and may have a modest effect in slowing disability progression. In addition to the common antiviral activity, IFN beta also induces increased production of the p53 gene product which promotes apoptosis, and thus has therapeutic effect against certain cancers. The role of IFN-beta in bone metabolism could warrant its systematic evaluation as a potential adjunct to therapeutic regimens of osteolytic diseases. Furthermore, IFN beta might play a beneficial role in the development of a chronic progressive CNS inflammation.

IFN-beta の参考文献

  • Kohriyama T, et al. (2008) Interferon-beta treatment for multiple sclerosis and predictors of response. Nippon Rinsho. 66(6): 1119-26.
  • Stbgen JP. (2009) Recombinant interferon-beta therapy and neuromuscular disorders. J Neuroimmunol. 212(1-2): 132-41.
  • Abraham AK, et al. (2009) Mechanisms of interferon-beta effects on bone homeostasis. Biochem Pharmacol. 77(12): 1757-62.