Anti-IFNAR1 Antibody (FITC)

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Anti-IFNAR1 Antibody (FITC) (Rabbit Monoclonal 抗体) の製品情報

製品名
Anti-IFNAR1 Antibody (FITC)
検証済のアプリケーション
FCM
交差反応
Reacts with: Mouse
特異性
Mouse IFNAR1
免疫原
Recombinant Mouse IFNAR1 protein (Catalog#50469-M08H)
調製
This antibody was obtained from a rabbit immunized with purified, recombinant Mouse IFNAR1 (rM IFNAR1; Catalog#50469-M08H; NP_034638.2; Met1-Thr429) and conjugated with FITC under optimum conditions, the unreacted FITC was removed.
ソース
Monoclonal Rabbit IgG Clone #110
精製
Protein A
緩衝液
Aqueous solution containing 0.5% BSA and 0.09% sodium azide
標識物
FITC
濃度
10 μl/Test, 0.1 mg/ml
状態
Liquid
配送方法
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
保存条件
This antibody can be stored at 2℃-8℃ for twelve months without detectable loss of activity. Protected from prolonged exposure to light. Do not freeze ! Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.

Anti-IFNAR1 Antibody (FITC) (Rabbit Monoclonal 抗体) の画像

Analysis of IFNAR1 expression on spleen lymphocytes.

Anti-IFNAR1 Antibody (FITC): 別名

Anti-CD118 Antibody; Anti-Ifar Antibody; Anti-Ifnar Antibody; Anti-Ifrc Antibody; Anti-Infar Antibody

IFNAR1 背景情報

Interferon-alpha/beta receptor alpha chain (IFNAR1) is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. The encoded protein also functions as an antiviral factor. Tyk2 slows down IFNAR1 degradation and that this is due, at least in part, to inhibition of IFNAR1 endocytosis. Mutant versions of IFNAR1, in which Tyr466 is changed to phenylalanine, can act in a dominant negative manner to inhibit phosphorylation of STAT2. These observations are consistent with a model in which IFNAR1 mediates the interaction between JAK kinases and the STAT transcription factors.
完全な名称
interferon (alpha, beta and omega) receptor 1
参考文献
  • Yan H, et al. (1996) Phosphorylated interferon-alpha receptor 1 subunit (IFNaR1) acts as a docking site for the latent form of the 113 kDa STAT2 protein. EMBO J. 15(5): 1064-74.
  • Richter MF, et al. (1998) Specific contribution of Tyk2 JH regions to the binding and the expression of the interferon alpha/beta receptor component IFNAR1. J Biol Chem. 273(38): 24723-9.
  • Abramovich C, et al. (1997) A protein-arginine methyltransferase binds to the intracytoplasmic domain of the IFNAR1 chain in the type I interferon receptor. EMBO J. 16(2): 260-6.

Standard Antibody Development Service

Rabbit MAb

Mouse MAb

Rabbit PAb

Fast Antibody Development Service

Mouse MAb

Rabbit PAb

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