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Interferon Gamma/IFN gamma/IFNG  Protein, Antibody, ELISA Kit, cDNA Clone

製品の説明: Active  
発現宿主: CHO Stable Cells  
  • Slide 1
11725-HNAS-500
11725-HNAS-100
11725-HNAS-1
11725-HNAS-20
500 µg 
100 µg 
1 mg 
20 µg 
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製品の説明: Active  
発現宿主: Human Cells  
  • Slide 1
50709-M02H-20
50709-M02H-100
20 µg 
100 µg 
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製品の説明: Active  
発現宿主: Human Cells  
  • Slide 1
50709-M08H-20
50709-M08H-100
20 µg 
100 µg 
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製品の説明:   
発現宿主: Human Cells  
  • Slide 1
50709-MNAH-100
50709-MNAH-200
100 µg 
200 µg 
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製品の説明: Active  
発現宿主: Human Cells  
  • Slide 1
80234-R02H-100
80234-R02H-20
80234-R02H-5
100 µg 
20 µg 
5 µg 
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発現宿主: E. coli  
  • Slide 1
90008-CNAE-20
90008-CNAE-50
20 µg 
50 µg 
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発現宿主: Human Cells  
  • Slide 1
90008-C08H-20
90008-C08H-100
20 µg 
100 µg 
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Interferon Gamma/IFN gamma/IFNG 関連経路

    Interferon Gamma/IFN gamma/IFNG 関連製品

    Interferon Gamma/IFN gamma/IFNG サマリー & タンパク質情報

    Interferon Gamma/IFN gamma/IFNG 背景

    遺伝子の概要: IFNG gene encodes a member of the type II interferon family. The protein encoded is a soluble cytokine with antiviral, immunoregulatory and anti-tumor properties and is a potent activator of macrophages. Mutations in IFNG gene are associated with aplastic anemia.
    General information above from NCBI
    サブユニット構造: Homodimer.
    細胞内位置: Secreted.
    組織特異性: Released primarily from activated T lymphocytes.
    翻訳後: Proteolytic processing produces C-terminal heterogeneity, with proteins ending alternatively at Gly-150, Met-157 or Gly-161.
    疾患関連性: Aplastic anemia (AA) [MIM:609135]: A form of anemia in which the bone marrow fails to produce adequate numbers of peripheral blood elements. It is characterized by peripheral pancytopenia and marrow hypoplasia. Note=Disease susceptibility may be associated with variations affecting the gene represented in this entry.
    シーケンスの類似性: Belongs to the type II (or gamma) interferon family.
    General information above from UniProt

    IFN gamma, also known as IFNG, is a secreted protein which belongs to the type I I interferon family. IFN gamma is produced predominantly by natural killer and natural killer T cells as part of the innate immune response, and by CD4 and CD8 cytotoxic T lymphocyte effector T cells once antigen-specific immunity develops. IFN gamma has antiviral, immunoregulatory, and anti-tumor properties. IFNG, in addition to having antiviral activity, has important immunoregulatory functions, it is a potent activator of macrophages, and has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. The IFNG monomer consists of a core of six α-helices and an extended unfolded sequence in the C-terminal region. IFN gamma is critical for innate and adaptive immunity against viral and intracellular bacterial infections and for tumor control. Aberrant IFN gamma expression is associated with a number of autoinflammatory and autoimmune diseases. The importance of IFN gamma in the immune system stems in part from its ability to inhibit viral replication directly, and most importantly from its immunostimulatory and immunomodulatory effects. IFNG also promotes NK cell activity.

    Interferon Gamma/IFN gamma/IFNG 代替名

    IFG,IFI, [homo-sapiens]
    IFG,IFI,IFN gamma,IFNG,immune interferon,interferon gamma, [human]
    gamma interferon,Ifg,IFN gamma,Ifng,IFN-g, [mouse]
    Ifg,IFN-g, [mus-musculus]

    Interferon Gamma/IFN gamma/IFNG 関連研究

  • Gray P W, et al. (1982) Structure of the human immune interferon gene. Nature. 298: 859-63.
  • Taya Y, et al. (1982) Cloning and structure of the human immune interferon-gamma chromosomal gene. EMBO J. 1: 953-8.
  • Goshima N, et al. (2008) Human protein factory for converting the transcriptome into an in vitro-expressed proteome. Nomura N Nat Methods. 5: 1011-7.
  • Thiel DJ, et al. (2000) Observation of an unexpected third receptor molecule in the crystal structure of human interferon-gamma receptor complex. Structure. 8 (9): 927-36.
  • Naylor SL, et al. (1983) Human immune interferon gene is located on chromosome 12. J Exp Med. 157 (3): 1020-7.
  • Schoenborn JR, et al. (2007) Regulation of interferon-gamma during innate and adaptive immune responses. Adv Immunol. 96: 41-101.
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