Interferon Gamma (タンパク質 | 抗体 | cDNA クローン | ELISA キット)

All Interferon Gamma reagents are produced in house and quality controlled, including 19 Interferon Gamma Antibody, 2 Interferon Gamma ELISA, 65 Interferon Gamma Gene, 8 Interferon Gamma Lysate, 9 Interferon Gamma Protein, 3 Interferon Gamma qPCR. All Interferon Gamma reagents are ready to use.

Interferon Gamma Protein (9)

Interferon Gamma Antibody (19)

Interferon Gamma ELISA キット(すぐに使用できます)& ELISA抗体ペアセット(すぐに使用できません)(2)

Interferon Gamma cDNA Clone (65)

BC070256

クローニングベクター cDNA 製品

In lentiviral vector

NM_008337.3

クローニングベクター cDNA 製品

In lentiviral vector

NM_138880.2

クローニングベクター cDNA 製品

In lentiviral vector

AB300566.1

クローニングベクター cDNA 製品

In lentiviral vector

NM_001032905.1

クローニングベクター cDNA 製品

In lentiviral vector

Interferon Gamma Lysate (8)

Interferon Gamma の背景知識

IFN gamma, also known as IFNG, is a secreted protein which belongs to the type I I interferon family. IFN gamma is produced predominantly by natural killer and natural killer T cells as part of the innate immune response, and by CD4 and CD8 cytotoxic T lymphocyte effector T cells once antigen-specific immunity develops. IFN gamma has antiviral, immunoregulatory, and anti-tumor properties. IFNG, in addition to having antiviral activity, has important immunoregulatory functions, it is a potent activator of macrophages, and has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. The IFNG monomer consists of a core of six α-helices and an extended unfolded sequence in the C-terminal region. IFN gamma is critical for innate and adaptive immunity against viral and intracellular bacterial infections and for tumor control. Aberrant IFN gamma expression is associated with a number of autoinflammatory and autoimmune diseases. The importance of IFN gamma in the immune system stems in part from its ability to inhibit viral replication directly, and most importantly from its immunostimulatory and immunomodulatory effects. IFNG also promotes NK cell activity.

Interferon Gamma の参考文献

  • Gray P W, et al. (1982) Structure of the human immune interferon gene. Nature. 298: 859-63.
  • Taya Y, et al. (1982) Cloning and structure of the human immune interferon-gamma chromosomal gene. EMBO J. 1: 953-8.
  • Goshima N, et al. (2008) Human protein factory for converting the transcriptome into an in vitro-expressed proteome. Nomura N Nat Methods. 5: 1011-7.
  • Thiel DJ, et al. (2000) Observation of an unexpected third receptor molecule in the crystal structure of human interferon-gamma receptor complex. Structure. 8 (9): 927-36.
  • Naylor SL, et al. (1983) Human immune interferon gene is located on chromosome 12. J Exp Med. 157 (3): 1020-7.
  • Schoenborn JR, et al. (2007) Regulation of interferon-gamma during innate and adaptive immune responses. Adv Immunol. 96: 41-101.