ICOS ligand (タンパク質 | 抗体 | cDNA クローン | ELISA キット)

All ICOS ligand reagents are produced in house and quality controlled, including 13 ICOS ligand Antibody, 1 ICOS ligand ELISA, 28 ICOS ligand Gene, 8 ICOS ligand Lysate, 9 ICOS ligand Protein, 2 ICOS ligand qPCR. All ICOS ligand reagents are ready to use.

ICOS ligand Protein (9)

ICOS ligand Antibody (13)

ICOS ligand ELISA キット(すぐに使用できます)& ELISA抗体ペアセット(すぐに使用できません)(1)

ICOS ligand cDNA Clone (28)

NM_001283050.1

In expression vector

NM_015259.4
NM_015790.3

クローニングベクター cDNA 製品

In lentiviral vector

XM_006256262.1

クローニングベクター cDNA 製品

XM_005548562.3

クローニングベクター cDNA 製品

ICOS ligand Lysate (8)

ICOS ligand の背景知識

Inducible co-stimulator ligand (ICOSL), also known as B7-H2, is a member of the B7 family of co-stimulatory molecules related to B7-1 and B7-2. It is a transmembrane glycoprotein with extracellular IgV and IgC domains, and binds to ICOS on activated T cells, thus delivers a positive costimulatory signal for optimal T cell function. The structural features of ICOSL are crucial for its costimulatory function. Present study shows that ICOSL displays a marked oligomerization potential, resembling more like B7-1 than B7-2. B7-H2-dependent signaling may play an active role in a proliferative response rather than in cytokine and chemokine production. The CD28/B7 and ICOS/B7-H2 pathways are both critical for costimulating T cell immune responses. Deficiency in either pathway results in defective T cell activation, cytokine production and germinal center formation.

ICOS ligand の参考文献

  • Flesch IE. (2002) Inducible costimulator-ligand (ICOS-L). J Biol Regul Homeost Agents. 16(3): 217-9.
  • Kajiwara K, et al. (2009) Expression and function of the inducible costimulator ligand B7-H2 in human airway smooth muscle cells. Allergol Int. 58(4): 573-83.
  • Wong SC, et al. (2009) Functional hierarchy and relative contribution of the CD28/B7 and ICOS/B7-H2 costimulatory pathways to T cell-mediated delayed-type hypersensitivity. Cell Immunol. 256(1-2): 64-71.