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人々 NRG1/Neuregulin 1 transcript variant HRG-beta2 Gene ORF cDNA clone expression plasmid

    データシートレビュー関連製品プロトコル
    人々 NRG1 cDNA クローン製品情報
    Gene_bank_ref_id:NM_013957.3
    cDNA サイズ:1914bp
    cDNA の説明:Full length Clone DNA of Homo sapiens neuregulin 1 transcript variant HRG-beta2.
    遺伝子の別名:GGF, HGL, HRG, NDF, ARIA, GGF2, HRG1, HRGA, SMDF
    :Human
    ベクター:pCMV3-untagged
    Plasmid:
    制限サイト:
    タグ シーケンス:
    シーケンスの説明:
    Sequencing primers:T7(TAATACGACTCACTATAGGG) BGH(TAGAAGGCACAGTCGAGG)
    ( We provide with NRG1 qPCR primers for gene expression analysis, HP100872 )
    Promoter:Enhanced CMV mammalian cell promoter
    Application:Stable or Transient mammalian expression
    Antibiotic in E.coli:Ampicillin
    Antibiotic in mammalian cell:Hygromycin
    Shipping_carrier:Each tube contains lyophilized plasmid.
    保存:The lyophilized plasmid can be stored at room temperature for three months.
    人々 NRG1/Neuregulin 1 transcript variant HRG-beta2 Gene ORF cDNA clone expression plasmid on other vectors
    人々 NRG1/Neuregulin 1 transcript variant HRG-beta2 Gene ORF cDNA clone expression plasmid, C-GFPSpark タグHG10658-ACGJPY59240
    人々 NRG1/Neuregulin 1 transcript variant HRG-beta2 Gene ORF cDNA clone expression plasmid, C-OFPSpark タグHG10658-ACRJPY59240
    人々 NRG1/Neuregulin 1 transcript variant HRG-beta2 Gene ORF cDNA clone expression plasmid, C-Flag タグHG10658-CFJPY51990
    人々 NRG1/Neuregulin 1 transcript variant HRG-beta2 Gene ORF cDNA clone expression plasmid, C-His タグHG10658-CHJPY51990
    人々 NRG1/Neuregulin 1 transcript variant HRG-beta2 Gene ORF cDNA clone expression plasmid, C-Myc タグHG10658-CMJPY51990
    人々 NRG1/Neuregulin 1 transcript variant HRG-beta2 Gene ORF cDNA clone expression plasmid, C-HA タグHG10658-CYJPY51990
    人々 NRG1/Neuregulin 1 transcript variant HRG-beta2 Gene ORF cDNA clone in cloning vectorHG10658-MJPY18140
    人々 NRG1/Neuregulin 1 transcript variant HRG-beta2 Gene ORF cDNA clone expression plasmid, N-Flag タグHG10658-NFJPY51990
    人々 NRG1/Neuregulin 1 transcript variant HRG-beta2 Gene ORF cDNA clone expression plasmid, N-His タグHG10658-NHJPY51990
    人々 NRG1/Neuregulin 1 transcript variant HRG-beta2 Gene ORF cDNA clone expression plasmid, N-Myc タグHG10658-NMJPY51990
    人々 NRG1/Neuregulin 1 transcript variant HRG-beta2 Gene ORF cDNA clone expression plasmid, N-HA タグHG10658-NYJPY51990
    人々 NRG1/Neuregulin 1 transcript variant HRG-beta2 Gene ORF cDNA clone expression plasmidHG10658-UTJPY51990
     発現ベクターの詳細情報
    Product nameProduct name
    背景

    Neuregulin 1 or NRG1 is one of four proteins in the neuregulin family that act on the EGFR family of receptors. This growth factor was originally identified as a 44-kD glycoprotein that interacts with the NEU / ERBB2 receptor tyrosine kinase to increase its phosphorylation on tyrosine residues. NRG1 is a trophic factor that has been implicated in neural development, neurotransmission, and synaptic plasticity. NRG1 has multiple isoforms that are generated by usage of different promoters and alternative splicing of a single gene. Neuregulin 1 (NRG1) is essential for the development and function of multiple organ systems, and its dysregulation has been linked to diseases such as cancer and schizophrenia. NRG1 is a schizophrenia candidate gene and plays an important role in brain development and neural function. Schizophrenia is a complex disorder, with etiology likely due to epistasis. 

    参考文献
  • Nicodemus KK, et al. (2010) Biological validation of increased schizophrenia risk with NRG1, ERBB4, and AKT1 epistasis via functional neuroimaging in healthy controls. Arch Gen Psychiatry. 67 (10): 991-1001.
  • Tan W, et al. (2007) Molecular cloning of a brain-specific, developmentally regulated neuregulin 1 (NRG1) isoform and identification of a functional promoter variant associated with schizophrenia. J Biol Chem. 282 (33): 24343-51.
  • Holmes WE, et al. (1992) Identification of heregulin, a specific activator of p185erbB2. Science. 256 (5060): 1205-10.
  • Size / Price
    カタログ: HG10658-UT
    定価: 
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