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人々 Peroxiredoxin 1/PRDX1 Gene ORF cDNA clone expression plasmid

データシートレビュー関連製品プロトコル
Human PRDX1 cDNA クローン製品情報
Gene_bank_ref_id:BC007063.1
cDNA サイズ:600bp
cDNA の説明:Full length Clone DNA of Homo sapiens peroxiredoxin 1.
遺伝子の別名:PAG, PAGA, PAGB, PRX1, PRXI, MSP23, NKEFA, TDPX2, PRDX1
:Human
ベクター:pCMV3-untagged
Plasmid:pCMV3-PRDX1
制限サイト:KpnI + XbaI (6.1kb + 0.6kb)
タグ シーケンス:
シーケンスの説明:Identical with the Gene Bank Ref. ID sequence.
Sequencing primers:T7(TAATACGACTCACTATAGGG) BGH(TAGAAGGCACAGTCGAGG)
Promoter:Enhanced CMV mammalian cell promoter
Application:Stable or Transient mammalian expression
Antibiotic in E.coli:Ampicilin
Antibiotic in mammalian cell:Hygromycin
Shipping_carrier:Each tube contains lyophilized plasmid.
保存:The lyophilized plasmid can be stored at room temperature for three months.
Human PRDX1 Gene Plasmid Map
Human PRDX1 Gene cDNA Clone (full-length ORF Clone), expression ready, untagged
人々 Peroxiredoxin 1/PRDX1 Gene ORF cDNA clone expression plasmid on other vectors
人々 Peroxiredoxin 1/PRDX1 Gene ORF cDNA clone expression plasmid, C-GFPSpark タグHG11194-ACGJPY54410
人々 Peroxiredoxin 1/PRDX1 Gene ORF cDNA clone expression plasmid, C-OFPSpark タグHG11194-ACRJPY54410
人々 Peroxiredoxin 1/PRDX1 Gene ORF cDNA clone expression plasmid, N-GFPSpark タグHG11194-ANGJPY54410
人々 Peroxiredoxin 1/PRDX1 Gene ORF cDNA clone expression plasmid, N-OFPSpark タグHG11194-ANRJPY54410
人々 Peroxiredoxin 1/PRDX1 Gene ORF cDNA clone expression plasmid, C-Flag タグHG11194-CFJPY47150
人々 Peroxiredoxin 1/PRDX1 Gene ORF cDNA clone expression plasmid, C-His タグHG11194-CHJPY47150
人々 Peroxiredoxin 1/PRDX1 Gene ORF cDNA clone expression plasmid, C-Myc タグHG11194-CMJPY47150
人々 Peroxiredoxin 1/PRDX1 Gene ORF cDNA clone expression plasmid, C-HA タグHG11194-CYJPY47150
人々 Peroxiredoxin 1/PRDX1 Gene ORF cDNA clone in cloning vectorHG11194-MJPY18140
人々 Peroxiredoxin 1/PRDX1 Gene ORF cDNA clone expression plasmid, C-Flag タグHG11194-M-FJPY47150
人々 Peroxiredoxin 1/PRDX1 Gene ORF cDNA clone expression plasmid, N-Flag タグHG11194-NFJPY47150
人々 Peroxiredoxin 1/PRDX1 Gene ORF cDNA clone expression plasmid, N-His タグHG11194-NHJPY47150
人々 Peroxiredoxin 1/PRDX1 Gene ORF cDNA clone expression plasmid, N-Myc タグHG11194-NMJPY47150
人々 Peroxiredoxin 1/PRDX1 Gene ORF cDNA clone expression plasmid, N-HA タグHG11194-NYJPY47150
人々 Peroxiredoxin 1/PRDX1 Gene ORF cDNA clone expression plasmidHG11194-UTJPY47150
 発現ベクターの詳細情報
Product nameProduct name
背景

Peroxiredoxin-1, also known as Thioredoxin peroxidase 2, Natural killer cell-enhancing factor A, PRDX1, and PAGA, is a member of the ahpC/TSA family. Peroxiredoxin-1 is constitutively expressed in most human cells. It is induced to higher levels upon serum stimulation in untransformed and transformed cells. Peroxiredoxins (PRDXs) are a family of antioxidant enzymes that are also known as scavengers of peroxide in mammalian cells. The overexpression of Peroxiredoxin-1, which is one of the peroxiredoxins that is a ubiquitously expressed protein, was related to a poor prognosis in several types of human cancers. Peroxiredoxin-1 is involved in redox regulation of the cell. It reduces peroxides with reducing equivalents provided through the thioredoxin system but not from glutaredoxin and may play an important role in eliminating peroxides generated during metabolism. Peroxiredoxin-1 Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H2O2. The reduced Peroxiredoxin-1 expression is an important factor in esophageal squamous cancer progression and could serve as a useful prognostic marker.

参考文献
  • Neumann, CA. et al., 2003, Nature 424 (6948): 561-5
  • Gisin, J. et al., 2005, J Clin Pathol. 58 (11): 1229-31.
  • Hoshino, I. et al., 2007, Oncol Rep. 18 (4): 867-71.
  • Cao, J. et al., 2009, EMBO J. 28 (10): 1505-17.
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    カタログ: HG11194-UT
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    • Human PRDX1 Gene cDNA Clone (full-length ORF Clone), expression ready, untagged
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