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HIV  gp120

HIV  gp120 タンパク質 & 抗体

GP120 タンパク質GP120 抗体GP120 cDNA クローンGP120 
Product NameMoleculeCat No.Package/Price 
HIV-1 gp120 蛋白質 (group M, subtype CRF07_BC) (His タグ)gp12011233-V08H-5
11233-V08H-100
11233-V08H-20
11233-V08H-50
5 µg/
100 µg/
20 µg/
50 µg/
Add to Cart
Add to Cart
Add to Cart
Add to Cart
HIV-1 gp160 蛋白質 (gp120 サブユニット) (group N, strain 06CM-U14296) (His タグ)gp12040255-V08H-5
40255-V08H-20
40255-V08H-100
40255-V08H-50
5 µg/
20 µg/
100 µg/
50 µg/
Add to Cart
Add to Cart
Add to Cart
Add to Cart
HIV-1 gp120 蛋白質 (group P, strain RBF168) (His タグ)gp12040259-V08H1-50
40259-V08H1-5
40259-V08H1-100
40259-V08H1-20
50 µg/
5 µg/
100 µg/
20 µg/
Add to Cart
Add to Cart
Add to Cart
Add to Cart
HIV-1 (group M, subtype B, strain SHIV-89.6P) gp120 蛋白質 (His タグ)gp12040402-V08H-5
40402-V08H-20
40402-V08H-50
40402-V08H-100
5 µg/
20 µg/
50 µg/
100 µg/
Add to Cart
Add to Cart
Add to Cart
Add to Cart
HIV-1 (group M, subtype A, isolate 92RW020) Envelope glycoprotein gp160 蛋白質 (gp120 サブユニット) (His タグ)gp12040403-V08H-5
40403-V08H-20
40403-V08H-50
40403-V08H-100
5 µg/
20 µg/
50 µg/
100 µg/
Add to Cart
Add to Cart
Add to Cart
Add to Cart
HIV-1 (group M, subtype B, isolate BAL) gp120 蛋白質 (His タグ)gp12040404-V08H-5
40404-V08H-20
40404-V08H-50
40404-V08H-100
5 µg/
20 µg/
50 µg/
100 µg/
Add to Cart
Add to Cart
Add to Cart
Add to Cart

HIV gp120 背景

The HIV-1 gp120 envelope protein, a glycoprotein that is part of the outer layer of the virus, which is an essential component in the multi-tiered viral entry process. It presents itself as viral membrane spikes consisting of 3 molecules of gp120 linked together and anchored to the membrane by gp41 protein. Gp120 is essential for viral infection as it facilitates HIV entry into the host cell and this is its best-known and most researched role in HIV infection. However, it is becoming increasingly evident that gp120 might also be facilitating viral persistence and continuing HIV infection by influencing the T cell immune response to the virus. The surface protein gp120 attaches the virus to the host lymphoid cell by binding to the primary receptor CD4. Gp120 binding to its receptor CD4 and co-receptor, CXCR4 or CCR5 is required for fusion of viral and cellular membranes. Several mechanisms might be involved in this process of which gp120 binding to the CD4 receptor of T cells is the best known and most important interaction as it facilitates viral entry into the CD4+ cells and their depletion, a hallmark of the HIV infection. Gp120 is shed from the viral membrane and accumulates in lymphoid tissues in significant amounts. Despite the overall genetic heterogeneity of the gp120 glycoprotein, the conserved CD4 binding site provides an attractive antiviral target. Interaction between gp120 and ITGA4/ITGB7 would allow the virus to enter GALT early in the infection, infecting and killing most of GALT's resting CD4+ T-cells. This T-cell depletion is believed to be the major insult to the host immune system leading to AIDS.

HIV gp120 関連研究

  1. Kadow J, et al. (2006) Small-molecule HIV-1 gp120 inhibitors to prevent HIV-1 entry: an emerging opportunity for drug development. Curr Opin Investig Drugs. 7(8): 721-6.
  2. Stevceva L, et al. (2007) Immune responses to HIV Gp120 that facilitate viral escape. Curr HIV Res. 5(1): 47-54.
  3. Yoon V, et al. (2010) The GP120 molecule of HIV-1 and its interaction with T cells. Curr Med Chem. 17(8): 741-9.
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