( We provide with IL17RD qPCR primers for gene expression analysis, HP100528 )
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
Human influenza hemagglutinin (HA) is a surface glycoprotein required for the infectivity of the human virus. The HA tag is derived from the HA-molecule corresponding to amino acids 98-106 has been extensively used as a general epitope tag in expression vectors. Many recombinant proteins have been engineered to express the HA tag, which does not appear to interfere with the bioactivity or the biodistribution of the recombinant protein. This tag facilitates the detection, isolation, and purification of the proteins.
The actual HA tag is as follows: 5' TAC CCA TAC GAT GTT CCA GAT TAC GCT 3' or 5' TAT CCA TAT GAT GTT CCA GAT TAT GCT 3' The amino acid sequence is: YPYDVPDYA.
|人々 IL-17RD Gene ORF cDNA clone expression plasmid, C-GFPSpark タグ||HG10507-ACG|
|人々 IL-17RD Gene ORF cDNA clone expression plasmid, C-OFPSpark タグ||HG10507-ACR|
|人々 IL-17RD Gene ORF cDNA clone expression plasmid, C-Flag タグ||HG10507-CF|
|人々 IL-17RD Gene ORF cDNA clone expression plasmid, C-His タグ||HG10507-CH|
|人々 IL-17RD Gene ORF cDNA clone expression plasmid, C-Myc タグ||HG10507-CM|
|人々 IL-17RD Gene ORF cDNA clone expression plasmid, C-HA タグ||HG10507-CY|
|人々 IL-17RD Gene ORF cDNA clone in cloning vector||HG10507-M|
|人々 IL-17RD Gene ORF cDNA clone expression plasmid, N-Flag タグ||HG10507-NF|
|人々 IL-17RD Gene ORF cDNA clone expression plasmid, N-His タグ||HG10507-NH|
|人々 IL-17RD Gene ORF cDNA clone expression plasmid, N-Myc タグ||HG10507-NM|
|人々 IL-17RD Gene ORF cDNA clone expression plasmid, N-HA タグ||HG10507-NY|
|人々 IL-17RD Gene ORF cDNA clone expression plasmid||HG10507-UT|
Interleukin-17 receptor D (IL-17D) also known as Interleukin-17 receptor-like protein, is a member of interleukine-17 recepter family. IL-17RD functions as a feedback inhibitor of fibroblast growth factor mediated Ras-MAPK signaling and ERK activation. It may inhibit FGF-induced FGFR1 tyrosine phosphorylation, regulate the nuclear ERK signaling pathway by spatially blocking nuclear translocation of activated ERK By similarity, and mediate JNK activation and may be involved in apoptosis. IL-17RD is found expressed in the neopallial cortex, rhombic lip and dorsal regions of the myelencephalon and in the frontal nasal process. IL-17RD is also expressed in the commissural plate and septal area of the forebrain and in the hippocampus, lens and optic cup. In the oral region, IL-17RD is expressed in the tongue and in the mesenchyme of the first branchial arch. It is also expressed in the developing inner ear. IL-17RD interacts with both IL-17R-Myc and IL-17RB-Myc. Both the intracellular and extracellular domains of IL-17RD interact with IL-17R. IL-17R forms a heteromeric complex with IL-17RD. Experiment results indicate that IL-17RD is able to affect IL-17R localization, suggesting that these two molecules are colocalized and associate with each other within cells. The fact that IL-17RD Delta ICD is unable to mediate IL-17 signaling but functions as a dominant-negative form indicates that the intracellular domain of IL-17RD is pivotal. In addition, IL-17RD interacts with the IL-17R downstream molecule TRAF6. It has been proposed that the IL-17RD intracellular domain interacts with IL-17R and TRAF6 to deliver the downstream signal.