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人々 IGF-2 / IGF-II 蛋白質

データシートレビュー関連製品プロトコル
Human IGF2 タンパク質製品情報
同意語:C11orf43,IGF-II,PP9974
タンパク質構造:A DNA sequence encoding the human IGF2 (ADO21454.1) (Ala25-Glu91) was expressed.
:Human
発現宿主:Yeast
フォーム & 配送:In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.
Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Human IGF2 タンパク質 QC 試験
純度:> 95 % as determined by SDS-PAGE
エンドトキシン:Please contact us for more information.
安定性:Samples are stable for up to twelve months from date of receipt at -70℃
予測される N ターミナル:Ala 25
分子質量:The recombinant human IGF2 consists 67 amino acids and predicts a molecular mass of 7.5 kDa.
製剤:Lyophilized from sterile 50 mM Tris, pH 8.0.
1. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
2. Please contact us for any concerns or special requirements.
Human IGF2 タンパク質使用ガイド
保存:Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
再構成:A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
Human IGF2 Protein SDS-PAGE
Human IGF-2 / IGF-II Protein

IGF2 関連経路

    Other IGF2 Recombinant Protein Products
    IGF-2/IGF-II 背景

    Insulin-like growth factor 2 (IGF-2/IGF-II) is a member of the insulin family of polypeptide growth factors, which are involved in development and growth. It is an imprinted gene, expressed only from the paternal allele, and epigenetic changes at this locus are associated with Wilms tumour, Beckwith-Wiedemann syndrome, rhabdomyosarcoma, and Silver-Russell syndrome. IGF-2/IGF-II is a mediator of prolactin-induced alveologenesis; prolactin, IGF-2, and cyclin D1, all of which are overexpressed in breast cancers, are components of a developmental pathway in the mammary gland. IGF-2 and exhibited statistically significant, positive associations with colorectal cancer risk when cases were confined to those diagnosed within a relatively short time period after enrolment. Circulating IGF-2 and IGFBP-3 can serve as early indicators of impending colorectal cancer. IGF-2/IGF-II appears to be involved in the progression of many tumours. It binds to at least two different types of receptor: IGF type 1 (IGF 1R) and mannose 6-phosphate/IGF type 2 (M6-P/IGF 2R). Ligand binding to IGF 1R provokes mitogenic and anti-apoptotic effects. M6-P/IGF 2R has a tumour suppressor function—it mediates IGF 2 degradation. Mutation of M6-P/IGF 2R causes both diminished growth suppression and augmented growth stimulation. The aim of this study was to investigate the role of IGF 2 and its receptors (IGF 1R and IGF 2R) in human gastric cancer.

    Human IGF-2/IGF-II 参考文献
  • Harvey MB, et al. (1991) IGF-2 receptors are first expressed at the 2-cell stage of mouse development. Development. 111(4): 1057-60.
  • Peters G, et al. (2003) IGF-1R, IGF-1 and IGF-2 expression as potential prognostic and predictive markers in colorectal-cancer. Virchows Arch. 443(2): 139-45.
  • Burrow S, et al. (1998) Expression of insulin-like growth factor receptor, IGF-1, and IGF-2 in primary and metastatic osteosarcoma. J Surg Oncol. 69(1): 21-7.
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    カタログ: 13032-HNAY-10
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    • Human IGF-2 / IGF-II Protein
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        All information of our products is subject to change without notice. Please refer to COA enclosed in shipped package for the newest information.
        注意:すべての製品は、"研究目的のみに使用するものであり、診断または治療目的に使用するものではありません"