IGF1 Protein, Human, Recombinant

Cat: 10598-HNAY
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IGF1 Protein, Human, Recombinant Product Information
Purity
> 95 % as determined by SDS-PAGE
Endotoxin
Please contact us for more information.
Activity
Measured in a cell proliferation assay using MCF-7 cells.
The ED50 for this effect is 15-60ng/mL.
Protein Construction
A DNA sequence encoding the human IGF1 (NP_001104754.1) (Gly49-Ala118) was expressed.
Accession#
Expressed Host
Yeast
Species
Human
Predicted N Terminal
Gly 49
Molecule Mass
The recombinant human IGF1 consists 70 amino acids and predicts a molecular mass of 7.7 kDa.
Formulation
Lyophilized from sterile PBS,pH 7.4.
1. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
2. Please contact us for any concerns or special requirements.
Please refer to the specific buffer information in the hard copy of CoA.
Shipping
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.
Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Stability & Storage
Samples are stable for up to twelve months from date of receipt at -70℃
Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution
A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
IGF1 Protein, Human, Recombinant in SDS-PAGE
Human IGF1/IGF‑I/IGF-1 Protein 8957
IGF1 Protein, Human, Recombinant Alternative Names
IGF-1 Protein, Human;IGF-I Protein, Human;IGF1A Protein, Human;IGFI Protein, Human;IGF‑I Protein, Human;MGF Protein, Human
IGF1 Background Information

IGF I, also known as mechano growth factor, somatomedin-C, IGF-I and IGF1, is a secreted protein which belongs to the?insulin family. The insulin family, comprised of insulin, relaxin, insulin-like growth factors I and II ( IGF-I and IGF-II ) and possibly the beta-subunit of 7S nerve growth factor, represents a group of structurally related polypeptides whose biological functions have diverged. The IGFs, or somatomedins, constitute a class of polypeptides that have a key role in pre-adolescent mammalian growth. IGF-I expression is regulated by GH and mediates postnatal growth, while IGF-II appears to be induced by placental lactogen during prenatal development. IGF1 / IGF-I may be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. IGF1 / IGF-I stimulates glucose transport in rat bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. Defects in IGF1 / IGF-I are the cause of insulin-like growth factor I deficiency (IGF1 deficiency) which is an autosomal recessive disorder characterized by growth retardation, sensorineural deafness and mental retardation.

Full Name
insulin-like growth factor 1 (somatomedin C)
References
  • Jansen M., et al.,(1983), Sequence of cDNA encoding human insulin-like growth factor I precursor. Nature 306:609-611.
  • de Pagter-Holthuizen P., et al., (1986), Organization of the human genes for insulin-like growth factors I and II.FEBS Lett. 195:179-184.
  • le Bouc Y., et al.,(1986), Complete characterization of the human IGF-I nucleotide sequence isolated from a newly constructed adult liver cDNA library.FEBS Lett. 196:108-112.
  • Other IGF1 Proteins

    Mouse IGF1 Proteins

    Product Name Cat.No.
    IGF1 Protein, Mouse, Recombinant 50437-MNAY

    Human IGF1 Proteins

    Product Name Cat.No.
    IGF1 Protein, Human, Recombinant 10598-HNAY1
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