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人々 CSRP1 Gene ORF cDNA clone expression plasmid

  • Human CSRP1 Gene cDNA Clone (full-length ORF Clone), expression ready, untagged
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人々 CSRP1 cDNA クローン製品情報
Gene_bank_ref_id:NM_004078.2
cDNA サイズ:582bp
cDNA の説明:Full length Clone DNA of Homo sapiens cysteine and glycine-rich protein 1.
遺伝子の別名:CRP, CRP1, CSRP, CYRP, D1S181E, DKFZp686M148, CSRP1
:Human
ベクター:pCMV3-untagged
Plasmid:pCMV3-CSRP1
制限サイト:HindIII + XbaI (6.1kb + 0.58kb)
タグ シーケンス:
シーケンスの説明:Identical with the Gene Bank Ref. ID sequence.
Sequencing primers:T7(TAATACGACTCACTATAGGG) BGH(TAGAAGGCACAGTCGAGG)
( We provide with CSRP1 qPCR primers for gene expression analysis, HP101106 )
Promoter:Enhanced CMV mammalian cell promoter
Application:Stable or Transient mammalian expression
Antibiotic in E.coli:Ampicillin
Antibiotic in mammalian cell:Hygromycin
Shipping_carrier:Each tube contains lyophilized plasmid.
保存:The lyophilized plasmid can be stored at room temperature for three months.
人々 CSRP1 Gene Plasmid Map
Human CSRP1 Gene cDNA Clone (full-length ORF Clone), expression ready, untagged
Product nameProduct name
背景

Cysteine and glycine-rich protein 1, also known as Cysteine-rich protein 1, CSRP1 and CSRP, is a member of the CSRP family which may be involved in regulatory processes important for development and cellular differentiation. CSRP1 contains two LIM zinc-binding domains. The LIM / double zinc-finger motif found in CSRP1 is found in a group of proteins with critical functions in gene regulation, cell growth, and somatic differentiation. Zebrafish CSRP1 is expressed in the mesendoderm and its derivatives. CSRP1 interacts with Dishevelled 2 (Dvl2) and Diversin (Div), which control cell morphology and other dynamic cell behaviors via the noncanonical Wnt and JNK pathways. When CSRP1 message is knocked down, abnormal convergent extension cell movement is induced, resulting in severe deformities in midline structures. In addition, cardiac bifida is induced as a consequence of defects in cardiac mesoderm cell migration. CSRP1 acts as a key molecule of the noncanonical Wnt pathway, which orchestrates cell behaviors during dynamic morphogenetic movements of tissues and organs.

参考文献
  • Wimmer,U. et al., 2005, Nucleic acids Res. 33 (18):5715-27.
  • Miyasaka, KY.et al., 2007, Proc Natl Acad Sci USA. 104 (27): 11274-9.
  • Zhou,C.Z. et al., 2008,Chin Med J. 121 (24): 2479-86.
  • Lilly,B. et al., 2010, Arterioscler Thromb Vasc Biol. 30 (4):694-701. 
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