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HVEM/TNFRSF14/CD270  Protein, Antibody, ELISA Kit, cDNA Clone

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発現宿主: Human Cells  
10334-H03H-200
10334-H03H-100
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100 µg 
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発現宿主: Human Cells  
10334-H08H-200
10334-H08H-100
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製品の説明: Active  
発現宿主: Human Cells  
10567-M03H-200
10567-M03H-100
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製品の説明: Active  
発現宿主: CHO Stable Cells  
10567-M03S-200
10567-M03S-100
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HVEM/TNFRSF14/CD270 Related Area

HVEM/TNFRSF14/CD270 関連経路

HVEM/TNFRSF14/CD270 関連製品

HVEM/TNFRSF14/CD270 サマリー & タンパク質情報

HVEM/TNFRSF14/CD270 背景

遺伝子の概要: The protein encoded by TNFRSF14 gene is a member of the TNF-receptor superfamily. This receptor was identified as a cellular mediator of herpes simplex virus (HSV) entry. Binding of HSV viral envelope glycoprotein D (gD) to this receptor protein has been shown to be part of the viral entry mechanism. The cytoplasmic region of this receptor was found to bind to several TRAF family members, which may mediate the signal transduction pathways that activate the immune response. [provided by RefSeq, Jul 2008]
General information above from NCBI
サブユニット構造: Interacts with TRAF2, TRAF3 and TRAF5. Interacts with herpes simplex virus 1 (HHV-1) and herpes simplex virus 1 (HHV-2) envelope glycoprotein D; functions as an entry receptor for these viruses. {ECO:0000269|PubMed:11511370, ECO:0000269|PubMed:16169851, ECO:0000269|PubMed:9153189, ECO:0000269|PubMed:9162022, ECO:0000269|PubMed:9696799}.
細胞内位置: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
組織特異性: Widely expressed, with the highest expression in lung, spleen and thymus.
翻訳後: N-glycosylated. {ECO:0000269|PubMed:16169851}.
シーケンスの類似性: Contains 3 TNFR-Cys repeats. {ECO:0000255|PROSITE-ProRule:PRU00206}.
General information above from UniProt

Herpesvirus entry mediator (HVEM), also referred to as TNFRSF14, TR2 (TNF receptor-like molecule) and ATAR (another TRAF-associated receptor), is a member of type I transmembrane protein belonging to the TNF-receptor superfamily. It is expressed on many immune cells, including T and B cells, NK cells, monocytes, and neutrophils. Two TNF superfamily ligands lymphotoxin α (TNF-β) and LIGHT (TNFSF14) are identified as cellular ligands for HVEM and initiate the positive signaling. However, recent studies have revealed that HVEM is also involved in the unique inhibitory signaling pathway for T cells through activating tyrosine phosphorylation of the immunoreceptor tyrosine-based inhibitory motif (ITIM) in B and T lymphocyte attenuator (BTLA). HVEM provides a stimulatory signal following engagement with LIGHT (TNFSF14) on T cells. In contrast, it can also provide an inhibitory signal to T cells when it binds the B and T lymphocyte attenuator (BTLA), a ligand member of the Immunoglobulin (Ig) superfamily. Thus, HVEM may be viewed as a molecular switch, capable of facilitating both stimulatory and inhibitory cosignaling in T cells. Substantial evidence from both human disease and from experimental mouse models has indicated that dysregulation of the LIGHT-HVEM-BTLA cosignaling pathway can cause inflammation in the lung and in mucosal tissues.

Immune Checkpoint
Immune Checkpoint Detection: Antibodies   Immune Checkpoint Detection: ELISA Antibodies
Immune Checkpoint Proteins
Immune Checkpoint Targets   Co-inhibitory Immune Checkpoint Targets

Immunotherapy   Cancer Immunotherapy   Targeted Therapy

HVEM/TNFRSF14/CD270 代替名

CD270, []
TR2,ATAR,HVEA,HVEM,CD270,LIGHTR, [homo-sapiens]
ATAR,HVEA,HVEM,LIGHTR,RP3-395M20.6,TNFRSF14,TR2, [human]
Atar,HveA,Hvem,MGC123498,MGC123499,RP24-89N4.1,Tnfrs14,Tnfrsf14, [mouse]
Atar,HveA,Hvem,Tnfrs14, [mus-musculus]

HVEM/TNFRSF14/CD270 関連研究

  • Murphy KM, et al. (2006) Balancing co-stimulation and inhibition with BTLA and HVEM. Nat Rev Immunol. 6(9): 671-81.
  • Heo SK, et al. (2007) HVEM signaling in monocytes is mediated by intracellular calcium mobilization. J Immunol. 179(9): 6305-10.
  • Steinberg MW, et al. (2008) A crucial role for HVEM and BTLA in preventing intestinal inflammation. J Exp Med. 205(6): 1463-76.
  • Pasero C, et al. (2009) A role for HVEM, but not lymphotoxin-beta receptor, in LIGHT-induced tumor cell death and chemokine production. Eur J Immunol. 39(9): 2502-14.
  • Cheung TC. Modulation of T cell proliferation through the LIGHT-HVEM-BTLA cosignaling pathway. Recent Pat DNA Gene Seq. 3(3): 177-82.
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