HDAC8 (タンパク質 | 抗体 | cDNA クローン | ELISA キット)

All HDAC8 reagents are produced in house and quality controlled, including 1 HDAC8 Antibody, 30 HDAC8 Gene, 2 HDAC8 Lysate, 2 HDAC8 Protein, 2 HDAC8 qPCR. All HDAC8 reagents are ready to use.

HDAC8 Protein (2)

    HDAC8 Antibody (1)

      HDAC8 cDNA Clone (30)

      NM_018486.1

      クローニングベクター cDNA 製品

      In lentiviral vector

      NM_027382.3

      クローニングベクター cDNA 製品

      In lentiviral vector

      HDAC8 Lysate (2)

        HDAC8 の背景知識

        Histone deacetylase 8, also known as HDAC8 and HDACL1, is a nucleus and cytoplasm protein which belongs to thehistone deacetylase family and HD type 1 subfamily. Histone deacetylases (HDACs) are a growing family of enzymes implicated in transcriptional regulation by affecting the acetylation state of core histones in the nucleus of cells.HDAC8 / HDACL1 is weakly expressed in most tissues. It expressed at higher level in heart, brain, kidney and pancreas and also in liver, lung, placenta, prostate and kidney. HDAC8 / HDACL1 is responsible for the deacetylation of lysine residues on the N-terminal part of the core histones ( H2A, H2B, H3 and H4 ). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. HDAC8 / HDACL1 may play a role in smooth muscle cell contractility. HDAC8 / HDACL1 may be a potential drug target for neuroblastoma differentiation therapy using selective inhibitors, avoiding unspecific side effects.

        HDAC8 の参考文献

        • Buggy JJ. et al.,2000, Biochem J. 350 (1): 199-205.
        • Krennhrubec K. et al., 2007, Bioorg Med Chem Lett. 17 (10): 2874-8.
        • Oehme I. et al., 2009, Expert Opin Investig Drugs.18 (11): 1605-17.