GITR (タンパク質 | 抗体 | cDNA クローン | ELISA キット)

All GITR reagents are produced in house and quality controlled, including 4 GITR Antibody, 29 GITR Gene, 5 GITR Lysate, 6 GITR Protein, 2 GITR qPCR. All GITR reagents are ready to use.

GITR Protein (6)

GITR Antibody (4)

GITR cDNA Clone (29)

NM_004195.2

クローニングベクター cDNA 製品

In lentiviral vector

NM_009400.2

クローニングベクター cDNA 製品

In lentiviral vector

NM_001024349.1

クローニングベクター cDNA 製品

In lentiviral vector

XM_005545123.2

クローニングベクター cDNA 製品

GITR Lysate (5)

GITR の背景知識

GITR, also known as TNFRSF18(CD357), belongs to the tumor necrosis factor receptor (TNF-R) superfamily. It is the receptor for TNFSF18. GITR plays a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells. GITR may be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. GITR and its ligand are important costimulatory molecules in the pathogenesis of autoimmune diseases. It also mediates NF-kappa-B activation via the TRAF2/NIK pathway.

GITR の参考文献

  • Kwon B, et al. (1999) Identification of a novel activation-inducible protein of the tumor necrosis factor receptor superfamily and its ligand. J Biol Chem. 274(10):6056-61.
  • Nocentini G, et al. (1997) A new member of the tumor necrosis factor/nerve growth factor receptor family inhibits T cell receptor-induced apoptosis. Proc Natl Acad Sci. 94(12): 6216-21.
  • Baltz KM, et al. (2007) Cancer immunoediting by GITR (glucocorticoid-induced TNF-related protein) ligand in humans: NK cell/tumor cell interactions. FASEB J. 21(10):2442-54.