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GITR/TNFRSF18/CD357  Protein, Antibody, ELISA Kit, cDNA Clone

発現宿主: Human Cells  
  • Slide 1
13643-H08H-20
13643-H08H-100
20 µg 
100 µg 
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発現宿主: Human Cells  
  • Slide 1
13643-H02H-50
13643-H02H-100
50 µg 
100 µg 
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発現宿主: Human Cells  
  • Slide 1
80192-R02H-50
80192-R02H-100
50 µg 
100 µg 
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GITR/TNFRSF18/CD357 Related Area

GITR/TNFRSF18/CD357 関連経路

GITR/TNFRSF18/CD357 関連製品

GITR/TNFRSF18/CD357 サマリー & タンパク質情報

GITR/TNFRSF18/CD357 背景

遺伝子の概要: This gene encodes a member of the TNF-receptor superfamily. GITR has been shown to have increased expression upon T-cell activation, and it is thought to play a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells. Knockout studies in mice also suggest the role of this receptor is in the regulation of CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript variants of this GITR gene encoding distinct isoforms have been reported. [provided by RefSeq, Feb 2011]
General information above from NCBI
サブユニット構造: Binds to TRAF1, TRAF2, and TRAF3, but not TRAF5 and TRAF6. Binds through its C-terminus to SIVA1/SIVA.
細胞内位置: Isoform 1: Cell membrane; Single-pass type I membrane protein.; Isoform 2: Secreted.
組織特異性: Expressed in lymph node, peripheral blood leukocytes and weakly in spleen.
誘導: Up-regulated in peripherical mononuclear cells after antigen stimulation/lymphocyte activation.
シーケンスの類似性: Contains 3 TNFR-Cys repeats. {ECO:0000305}.
General information above from UniProt

GITR, also known as TNFRSF18(CD357), belongs to the tumor necrosis factor receptor (TNF-R) superfamily. It is the receptor for TNFSF18. GITR plays a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells. GITR may be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. GITR and its ligand are important costimulatory molecules in the pathogenesis of autoimmune diseases. It also mediates NF-kappa-B activation via the TRAF2/NIK pathway.

Immune Checkpoint
Immune Checkpoint Detection: ELISA Antibodies
Immune Checkpoint Targets   Co-stimulatory Immune Checkpoint Targets

Immunotherapy   Cancer Immunotherapy   Targeted Therapy

GITR/TNFRSF18/CD357 代替名

activation-inducible TNFR family receptor,AITR,CD357,GITR,GITR-D,glucocorticoid-induced TNFR-related protein,RP5-902P8.2,TNF receptor superfamily activation-inducible protein,tumor necrosis factor receptor superfamily member 18, [human]
AITR,Gitr,glucocorticoid-induced TNFR-related protein,RP23-118E21.6,tumor necrosis factor receptor superfamily member 18, [mouse]

GITR/TNFRSF18/CD357 関連研究

  • Kwon B, et al. (1999) Identification of a novel activation-inducible protein of the tumor necrosis factor receptor superfamily and its ligand. J Biol Chem. 274(10):6056-61.
  • Nocentini G, et al. (1997) A new member of the tumor necrosis factor/nerve growth factor receptor family inhibits T cell receptor-induced apoptosis. Proc Natl Acad Sci. 94(12): 6216-21.
  • Baltz KM, et al. (2007) Cancer immunoediting by GITR (glucocorticoid-induced TNF-related protein) ligand in humans: NK cell/tumor cell interactions. FASEB J. 21(10):2442-54.
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