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EPHA3/Eph Receptor A3  Protein, Antibody, ELISA Kit, cDNA Clone

発現宿主: Human Cells  
11459-H08H-50
11459-H08H-100
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発現宿主: Human Cells  
51122-M08H-200
51122-M08H-100
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発現宿主: Human Cells  
51122-M02H-500
51122-M02H-200
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発現宿主: Baculovirus-Insect Cells  
51122-M20B-50
51122-M20B-20
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発現宿主: Baculovirus-Insect cells  
51122-MNCB-50
51122-MNCB-20
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発現宿主: Human Cells  
80465-R08H-500
80465-R08H-200
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発現宿主: Human Cells  
80465-R02H-500
80465-R02H-200
500 µg 
200 µg 
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発現宿主: Human Cells  
80155-R02H-50
80155-R02H-200
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200 µg 
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EPHA3/Eph Receptor A3 Related Area

EPHA3/Eph Receptor A3 関連経路

EPHA3/Eph Receptor A3 関連製品

EPHA3/Eph Receptor A3 サマリー & タンパク質情報

EPHA3/Eph Receptor A3 背景

遺伝子の概要: EPHA3 belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. EPHA3 encodes a protein that binds ephrin-A ligands. Two alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jul 2008]
General information above from NCBI
触媒活性: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. {ECO:0000255|PROSITE-ProRule:PRU10028}.
サブユニット構造: Heterotetramer upon binding of the ligand. The heterotetramer is composed of an ephrin dimer and a receptor dimer. Oligomerization is probably required to induce biological responses. Forms a ternary EFNA5-EPHA3-ADAM10 complex mediating EFNA5 extracellular domain shedding by ADAM10 which regulates the EFNA5-EPHA3 complex internalization and function. Interacts with NCK1 (via SH2 domain); mediates EFNA5-EPHA3 signaling (By similarity). Interacts (phosphorylated) with PTPN1; dephosphorylates EPHA3 and may regulate its trafficking and function. Interacts (phosphorylated) with CRK; mediates EFNA5-EPHA3 signaling through RHOA GTPase activation. {ECO:0000250, ECO:0000269|PubMed:11870224, ECO:0000269|PubMed:14660665, ECO:0000269|PubMed:16239146, ECO:0000269|PubMed:18547520, ECO:0000269|PubMed:21135139}.
細胞内位置: Isoform 1: Cell membrane; Single-pass type I membrane protein.; Isoform 2: Secreted.
組織特異性: Widely expressed. Highest level in placenta.
翻訳後: Autophosphorylates upon activation by EFNA5. Phosphorylation on Tyr-602 mediates interaction with NCK1. Dephosphorylated by PTPN1. {ECO:0000269|PubMed:11870224, ECO:0000269|PubMed:18547520, ECO:0000269|PubMed:21135139}.
疾患関連性: DISEASE: Colorectal cancer (CRC) [MIM:114500]: A complex disease characterized by malignant lesions arising from the inner wall of the large intestine (the colon) and the rectum. Genetic alterations are often associated with progression from premalignant lesion (adenoma) to invasive adenocarcinoma. Risk factors for cancer of the colon and rectum include colon polyps, long-standing ulcerative colitis, and genetic family history. Note=The gene represented in this entry may be involved in disease pathogenesis.
シーケンスの類似性: Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily. {ECO:0000255|PROSITE-ProRule:PRU00159}.; Contains 1 Eph LBD (Eph ligand-binding) domain. {ECO:0000255|PROSITE-ProRule:PRU00883}.; Contains 2 fibronectin type-III domains. {ECO:0000255|PROSITE-ProRule:PRU00316}.; Contains 1 protein kinase domain. {ECO:0000255|PROSITE-ProRule:PRU00159}.; Contains 1 SAM (sterile alpha motif) domain. {ECO:0000255|PROSITE-ProRule:PRU00184}.
General information above from UniProt

EPHA3 gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. EPHA3 gene encodes a protein that binds ephrin-A ligands. EPHA3 is involved in the retinotectal mapping of neurons. It may also control the segregation but not the guidance of motor and sensory axons during neuromuscular circuit development.

Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

EPHA3/Eph Receptor A3 代替名

EK4,HEK,ETK1,HEK4,TYRO4,ETK, [homo-sapiens]
EK4,EPH receptor A3,EPHA3,EPH-like kinase 4,eph-like tyrosine kinase 1,ephrin type-A receptor 3,ETK,ETK1,HEK,HEK4,human embryo kinase 1,TYRO4,TYRO4 protein tyrosine kinase,tyrosine-protein kinase receptor ETK1, [human]
MEK4,ETK1,AW492086,Cek4,EK4,End3,Eph receptor A3,Epha3,EPH-like kinase 4,ephrin type-A receptor 3,Hek,Hek4,Tyro4,tyrosine-protein kinase receptor ETK1,tyrosine-protein kinase TYRO4, [mouse]
Hek,Cek4,ETK1,End3,Hek4,Mek4,Tyro4,AW492086, [mus-musculus]

EPHA3/Eph Receptor A3 関連研究

  • Holder N, et al. (1999) Eph receptors and ephrins: effectors of morphogenesis. Development. 126(10):2033-44.
  • Wilkinson DG. (2000) Eph receptors and ephrins: regulators of guidance and assembly. Int Rev Cytol. 196:177-244.
  • Xu Q, et al. (2001) Roles of Eph receptors and ephrins in segmental patterning. Philos Trans R Soc Lond B Biol Sci. 355(1399):993-1002.
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