EGFR (タンパク質 | 抗体 | cDNA クローン | ELISA キット)

All EGFR reagents are produced in house and quality controlled, including 31 EGFR Antibody, 2 EGFR ELISA, 52 EGFR Gene, 2 EGFR IP Kit, 16 EGFR Lysate, 16 EGFR Protein, 3 EGFR qPCR. All EGFR reagents are ready to use.

EGFR Protein (16)

EGFR Antibody (31)

EGFR ELISA キット(すぐに使用できます)& ELISA抗体ペアセット(すぐに使用できません)(2)

EGFR cDNA Clone (52)

NM_005228.3
NM_207655.2

クローニングベクター cDNA 製品

In lentiviral vector

HM801041.1

クローニングベクター cDNA 製品

In lentiviral vector

XM_533073.3

クローニングベクター cDNA 製品

In lentiviral vector

EGFR Lysate (16)

EGFR の背景知識

As a member of the epidermal growth factor receptor (EGFR) family, EGFR protein is type I transmembrane glycoprotein that binds a subset of EGF family ligands including EGF, amphiregulin, TGF-α, betacellulin, etc. EGFR protein plays a crucial role in signaling pathway in the regulation of cell proliferation, survival and differentiation. Binding of a ligand induces EGFR protein homo- or heterodimerization, the subsequent tyrosine autophosphorylation and initiates various down stream pathways (MAPK, PI3K/PKB and STAT). In addition, EGFR signaling also has been shown to exert action on carcinogenesis and disease progression, and thus EGFR protein is proposed as a target for cancer therapy currently.

EGFR の参考文献

  • Schlessinger, J. (2000) Cell signaling by receptor tyrosine kinases. Cell 103(2): 211-25.
  • Giaccone, G. (2005) HER1/EGFR-targeted agents: predicting the future for patients with unpredictable outcomes to therapy. Ann. Oncol. 16(4): 538-48.
  • Yarden, Y., et al. (2001) Untangling the ErbB signalling network. Nat. Rev. Mol. Cell. Biol. 2(2): 127-37.