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Epidermal Growth Factor/EGF  Protein, Antibody, ELISA Kit, cDNA Clone

製品の説明: Active  
発現宿主: Human Cells  
10605-H01H-500
10605-H01H-100
10605-H01H-1
500 µg 
100 µg 
1 mg 
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製品の説明: Active  
発現宿主: E. coli  
10605-HNAE-500
10605-HNAE-100
10605-HNAE-1
500 µg 
100 µg 
1 mg 
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製品の説明: Active  
発現宿主: Human Cells  
50482-M01H-500
50482-M01H-100
50482-M01H-1
500 µg 
100 µg 
1 mg 
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発現宿主: Human Cells  
50482-M08H1-50
50482-M08H1-20
50 µg 
20 µg 
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製品の説明: Active  
発現宿主: Yeast  
50482-MNAY-500
50482-MNAY-100
50482-MNAY-1
500 µg 
100 µg 
1 mg 
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製品の説明: Active  
発現宿主: Human Cells  
50482-MNCH-500
50482-MNCH-100
50482-MNCH-1
500 µg 
100 µg 
1 mg 
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発現宿主: E. coli  
80446-RNAE-500
80446-RNAE-100
80446-RNAE-1
500 µg 
100 µg 
1 mg 
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製品の説明: Active  
発現宿主: E. coli  
70013-D07E-500
70013-D07E-100
70013-D07E-1
500 µg 
100 µg 
1 mg 
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  • Slide 1

Epidermal Growth Factor/EGF Related Area

Epidermal Growth Factor/EGF 関連経路

Epidermal Growth Factor/EGF サマリー & タンパク質情報

Epidermal Growth Factor/EGF 背景

遺伝子の概要: This gene encodes a member of the epidermal growth factor superfamily. The encoded protein is synthesized as a large precursor molecule that is proteolytically cleaved to generate the 53-amino acid epidermal growth factor peptide. This protein acts a potent mitogenic factor that plays an important role in the growth, proliferation and differentiation of numerous cell types. This protein acts by binding the high affinity cell surface receptor, epidermal growth factor receptor. Defects in this gene are the cause of hypomagnesemia type 4. Dysregulation of this gene has been associated with the growth and progression of certain cancers. Alternate splicing results in multiple transcript variants.
General information above from NCBI
サブユニット構造: Interacts with EGFR and promotes EGFR dimerization. Interacts with RHBDF2 (By similarity). Interacts with RHBDF1; may retain EGF in the endoplasmic reticulum and regulates its degradation through the endoplasmic reticulum-associated degradation (ERAD). {ECO:0000250, ECO:0000269|PubMed:12297050, ECO:0000269|PubMed:12620237, ECO:0000269|PubMed:20837704, ECO:0000269|PubMed:21029725, ECO:0000269|PubMed:21439629}.
細胞内位置: Membrane; Single-pass type I membrane protein.
組織特異性: Expressed in kidney, salivary gland, cerebrum and prostate. {ECO:0000269|PubMed:17671655}.
翻訳後: O-glycosylated with core 1-like and core 2-like glycans. It is uncertain if Ser-954 or Thr-955 is O-glycosylated. The modification here shows glycan heterogeneity: HexHexNAc (major) and Hex2HexNAc2 (minor). {ECO:0000269|PubMed:22171320}.
疾患関連性: DISEASE: Hypomagnesemia 4 (HOMG4) [MIM:611718]: A disorder characterized by massive renal hypomagnesemia and normal levels of serum calcium and calcium excretion. Clinical features include seizures, mild-to moderate psychomotor retardation, and brisk tendon reflexes. {ECO:0000269|PubMed:17671655}. Note=The disease is caused by mutations affecting the gene represented in this entry.
シーケンスの類似性: Contains 9 EGF-like domains. {ECO:0000255|PROSITE-ProRule:PRU00076}.; Contains 9 LDL-receptor class B repeats. {ECO:0000255|PROSITE-ProRule:PRU00461}.
General information above from UniProt

EGF is the founding member of the EGF-family of proteins. Members of this protein family have highly similar structural and functional characteristics. EGF contains 9 EGF-like domains and 9 LDL-receptor class B repeats. Human EGF is a 6045-Da protein with 53 amino acid residues and three intramolecular disulfide bonds. As a low-molecular-weight polypeptide, EGF was first purified from the mouse submandibular gland, but since then it was found in many human tissues including submandibular gland, parotid gland. It can also be found in human platelets, macrophages, urine, saliva, milk, and plasma. EGF is a growth factor that stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. It results in cellular proliferation, differentiation, and survival. Salivary EGF, which seems also regulated by dietary inorganic iodine, also plays an important physiological role in the maintenance of oro-esophageal and gastric tissue integrity. EGF acts by binding with high affinity to epidermal growth factor receptor on the cell surface and stimulating the intrinsic protein-tyrosine kinase activity of the receptor. The tyrosine kinase activity, in turn, initiates a signal transduction cascade that results in a variety of biochemical changes within the cell - a rise in intracellular calcium levels, increased glycolysis and protein synthesis, and increases in the expression of certain genes including the gene for EGFR - that ultimately lead to DNA synthesis and cell proliferation.

Epidermal Growth Factor/EGF 代替名

Epidermal Growth Factor, []
URG,HOMG4, [homo-sapiens]
EGF,HOMG4,URG, [human]
AI790464,Egf, [mouse]
AI790464, [mus-musculus]

Epidermal Growth Factor/EGF 関連研究

  • Chen JX, et al. (2011) Involvement of c-Src/STAT3 signal in EGF-induced proliferation of rat spermatogonial stem cells. Mol Cell Biochem. 358(1-2):67-73.
  • Guo Y, et al. (2012) Correlations among ERCC1, XPB, UBE2I, EGF, TAL2 and ILF3 revealed by gene signatures of histological subtypes of patients with epithelial ovarian cancer. Oncol Rep. 27(1):286-92.
  • Kim S, et al. (2012) Smad7 acts as a negative regulator of the epidermal growth factor (EGF) signaling pathway in breast cancer cells. Cancer Lett. 314(2):147-54.
  • Chatterton RT Jr, et al. (2010) Breast ductal lavage for assessment of breast cancer biomarkers. Horm Cancer. 1(4):197-204.
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