E-Cadherin (タンパク質 | 抗体 | cDNA クローン | ELISA キット)

All E-Cadherin reagents are produced in house and quality controlled, including 22 E-Cadherin Antibody, 2 E-Cadherin ELISA, 28 E-Cadherin Gene, 5 E-Cadherin IP Kit, 7 E-Cadherin Lysate, 7 E-Cadherin Protein, 3 E-Cadherin qPCR. All E-Cadherin reagents are ready to use.

E-Cadherin Protein (7)

E-Cadherin Antibody (22)

E-Cadherin ELISA キット(すぐに使用できます)& ELISA抗体ペアセット(すぐに使用できません)(2)

E-Cadherin cDNA Clone (28)

NM_004360.3

クローニングベクター cDNA 製品

In lentiviral vector

NM_009864.2

In lentiviral vector

In expression vector

NM_031334.1

クローニングベクター cDNA 製品

In lentiviral vector

E-Cadherin Lysate (7)

E-Cadherin の背景知識

Cadherins are calcium-dependent cell adhesion proteins which preferentially interact with themselves in a homophilic manner in connecting cells, and thus may contribute to the sorting of heterogeneous cell type. E-cadherin (E-Cad), also known as CDH1 and CD324, is a calcium-dependent cell adhesion molecule the intact function of which is crucial for the establishment and maintenance of epithelial tissue polarity and structural integrity. Mutations in CDH1 occur in diffuse type gastric cancer, lobular breast cancer, and endometrial cancer. In human cancers, partial or complete loss of E-cadherin expression correlates with malignancy. During apoptosis or with calcium influx, E-Cad is cleaved by the metalloproteinase to produce fragments of about 38 kDa (E-CAD/CTF1), 33 kDa (E-CAD/CTF2) and 29 kDa (E-CAD/CTF3), respectively. E-Cad has been identified as a potent invasive suppressor, as downregulation of E-cadherin expression is involved in dysfunction of the cell-cell adhesion system, and often correlates with strong invasive potential and poor prognosis of human carcinomas.

E-Cadherin の参考文献

  • Wang HD, et al. (2004) CDH1 germline mutation in hereditary gastric carcinoma. World J Gastroenterol. 10(21): 3088-93.
  • Masterson J, et al. (2007) Posttranslational truncation of E-cadherin and significance for tumour progression. Cells Tissues Organs. 185(1-3): 175-9.
  • Mrgineanu E, et al. (2008) Correlation between E-cadherin abnormal expressions in different types of cancer and the process of metastasis. Rev Med Chir Soc Med Nat Iasi. 112(2): 432-6.