All DKK1 reagents are produced in house and quality controlled, including 10 DKK1 Antibody, 1 DKK1 ELISA, 25 DKK1 Gene, 1 DKK1 IPKit, 4 DKK1 Lysate, 4 DKK1 Protein, 1 DKK1 qPCR. All DKK1 reagents are ready to use.
Recombinant DKK1 proteins are expressed by HEK293 Cells with fusion tags as C-mouse IgG1-Fc, C-His.
DKK1antibodies are validated with different applications, which are ELISA, IHC-P, ELISA(Det), WB, Neutralization, IP, ELISA(Cap).
DKK1cDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each DKK1 of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.
DKK1ELISA Kit are quality controlled by 8 internation QC standard which guarantee every ELISA Kit with high quality.
Dickkopf (DKK) family proteins, consisting of DKK-1, DKK-2, DKK-3 and DKK-4, function as secreted Wnt antagonists by inhibiting Wnt coreceptors LRP5/6. DKK-1, DKK-2, and DKK-4 also bind cell surface Kremen-1 or Kremen-2 and promote the internalization of LRP5/6. Dickkopf related protein 1 (DKK-1) was initially identified as an inducer of head formation in Xenopus embryos. DKK-1 protein modulates Wnt signaling pathway during embryonic development. Increased levels of DKK-1 are found in the majority of lung cancers, esophageal squamous cell carcinomas, and hormone-resistant breast cancers, while DKK-1 expression is decreased in malignant melanoma and colorectal cancers.