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Complement component 7  Protein, Antibody, ELISA Kit, cDNA Clone

発現宿主: Human Cells  
13848-H08H-20
13848-H08H-100
20 µg 
100 µg 
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  • Slide 1
発現宿主: Human Cells  
13848-H02H-20
13848-H02H-100
20 µg 
100 µg 
Add to Cart
  • Slide 1

Complement component 7 Related Area

Complement component 7 関連経路

Complement component 7 サマリー & タンパク質情報

Complement component 7 背景

遺伝子の概要: Complement Component 7 is a component of the complement system. Complement Component 7 participates in the formation of Membrane Attack Complex (MAC). People with Complement Component 7 deficiency are prone to bacterial infection. [provided by RefSeq, Jul 2008]
General information above from NCBI
サブユニット構造: Monomer or dimer; as a C5b-7 complex it can also form multimeric rosettes. MAC assembly is initiated by protelytic cleavage of C5 into C5a and C5b. C5b binds sequentially C6, C7, C8 and multiple copies of the pore-forming subunit C9.
細胞内位置: Secreted.
翻訳後: C7 has 28 disulfide bridges.; O- and C-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans. {ECO:0000269|PubMed:10551839, ECO:0000269|PubMed:14760718, ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19139490, ECO:0000269|PubMed:22171320}.
疾患関連性: DISEASE: Complement component 7 deficiency (C7D) [MIM:610102]: A rare defect of the complement classical pathway associated with susceptibility to severe recurrent infections, predominantly by Neisseria gonorrhoeae or Neisseria meningitidis. {ECO:0000269|PubMed:8871666, ECO:0000269|PubMed:9218625, ECO:0000269|PubMed:9856499}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
シーケンスの類似性: Belongs to the complement C6/C7/C8/C9 family. {ECO:0000305}.; Contains 1 EGF-like domain. {ECO:0000305}.; Contains 1 LDL-receptor class A domain. {ECO:0000255|PROSITE-ProRule:PRU00124}.; Contains 1 MACPF domain. {ECO:0000255|PROSITE-ProRule:PRU00745}.; Contains 2 Sushi (CCP/SCR) domains. {ECO:0000255|PROSITE-ProRule:PRU00302}.; Contains 2 TSP type-1 domains. {ECO:0000255|PROSITE-ProRule:PRU00210}.
General information above from UniProt

Complement component 7 is a component of the complement system. It belongs to the complement C6/C7/C8/C9 family. It contains 1 EGF-like domain, 1 LDL-receptor class A domain, 1 MACPF domain, 2 Sushi (CCP/SCR) domains and 2 TSP type-1 domains. Complement component 7 serves as a membrane anchor. It participates in the formation of Membrane Attack Complex (MAC). People with C7 deficiency are prone to bacterial infection. It is a constituent of MAC that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. Defects in C7 are a cause of complement component 7 deficiency (C7D). A rare defect of the complement classical pathway associated with susceptibility to severe recurrent infections, predominantly by Neisseria gonorrhoeae or Neisseria meningitidis.

Complement component 7 代替名

complement component C7, [human]
A530026G17,complement component C7,Gm1238, [mouse]
Gm1238,A530026G17, [mus-musculus]

Complement component 7 関連研究

  • Bossi F, et al. (2009) C7 is expressed on endothelial cells as a trap for the assembling terminal complement complex and may exert anti-inflammatory function. Blood. 113(15):3640-8.
  • Kuijpers TW, et al. (2010) Complement factor 7 gene mutations in relation to meningococcal infection and clinical recurrence of meningococcal disease. Mol Immunol. 47(4):671-7.
  • Thomas AD, et al. (2012) Characterization of a large genomic deletion in four Irish families with C7 deficiency. Mol Immunol. 50(1-2):57-9.
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