C1s (Protein|Antibody|cDNA Clone|ELISA Kit)

All C1s reagents are produced in house and quality controlled, including 5 C1s Antibody, 1 C1s ELISA, 40 C1s Gene, 3 C1s qPCR. All C1s reagents are ready to use.

C1s antibodies are validated with different applications, which are ELISA, ELISA(Cap), ELISA(Det).

C1s cDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each C1s of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.

C1s ELISA Kit are quality controlled by 8 internation QC standard which guarantee every ELISA Kit with high quality.

C1s Antibody (5)

Application Clonality
Host

Anti-C1s Antibody

10220-MM02

Specificity: Human

Application: ELISA(Cap)

Clonality: MAb

Anti-C1s Antibody

10220-RP02

Specificity: Human

Application: ELISA

Clonality: PAb

Anti-C1s Antibody

10220-MM04

Specificity: Human

Application: ELISA(Det)

Clonality: MAb

Anti-C1s Antibody

10220-R006

Specificity: Human

Application: ELISA

Clonality: MAb

Anti-C1s Antibody

10220-RP01

Specificity: Human

Application: ELISA

Clonality: PAb

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C1s ELISA KIT & match antibody elias pair set ( 1 )

C1s Matched ELISA Antibody Pair Set,Human

SEK10220

Assay Range: 78.1 pg/ml

Human Complement C1s  ELISA Pair Set Standard Curve 13810

C1s cDNA Clone (40)

Human
Rat
Mouse

C1s qPCR Primer (3)

Complement is an integral component of the adaptive and innate immune systems and represents one of the major effector systems for the immune responses. The classical complement pathway is triggered by C1, a complex composed of the binding protein C1q and two proenzymes, C1r and C1s. Upon binding of IgG to the head of C1q, C1r undergoes autoactivation and in turn cleaves and activates C1s. C1r and C1s, the proteases responsible for activation and proteolytic activity of the C1 complex of complement, share similar overall structural organizations featuring five nonenzymic protein modules (two CUB modules surrounding a single EGF module, and a pair of CCP modules) followed by a serine protease domain. Besides highly specific proteolytic activities, both proteases exhibit interaction properties associated with their N-terminal regions. In contrast, C1r and C1s widely differ from each other by their glycosylation patterns: both proteins contain Asn-linked carbohydrates, but four glycosylation sites are present on C1r, and only two on C1s. As a highly specific serine protease, C1s executes the catalytic function of the C1 complex: the cleavage of C4 and C2, and thus instigates a sequence of activation steps of other components of the complement system, culminating in the formation of the membrane attack complex which induces cell lysis. Like other complement serine proteases C1s has restricted substrate specificity and it is engaged into specific interactions with other subcomponents of the complement system. The only other protein known to interact with C1s physiologically is SerpinC1, an inhibitor of serine protease, which inhibits C1s activity and thus plays a regulatory role in controlling the function of C1s enzyme.
Antibody
ELISA
Gene
qPCR
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