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Caspase-14/CASP14  Protein, Antibody, ELISA Kit, cDNA Clone

製品の説明: Active  
発現宿主: E. coli  
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Caspase-14/CASP14 サマリー & タンパク質情報

Caspase-14/CASP14 背景

遺伝子の概要: This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This caspase has been shown to be processed and activated by caspase 8 and caspase 10 in vitro, and by anti-Fas agonist antibody or TNF-related apoptosis inducing ligand in vivo. The expression and processing of this caspase may be involved in keratinocyte terminal differentiation, which is important for the formation of the skin barrier.
General information above from NCBI
サブユニット構造: Complex of unprocessed caspase-14 and processed 19 kDa (p19) and 10 kDa (p10) subunits. {ECO:0000269|PubMed:12200134}.
細胞内位置: Cytoplasm. Nucleus.
組織特異性: Expressed in keratinocytes of adult skin suprabasal layers (from spinous layers to the stratum granulosum and stratum corneum) (at protein level). Expressed in keratinocytes of hair shaft and sebaceous glands (at protein level). In psoriatic skin only expressed at very low levels. {ECO:0000269|PubMed:11175259}.
誘導: In undifferentiated keratinocytes under postconfluency growth conditions (in vitro). {ECO:0000269|PubMed:11175259}.
シーケンスの類似性: Belongs to the peptidase C14A family. {ECO:0000305}.
General information above from UniProt

Caspase 14 is a member of the caspase family. Caspases are a kind of cysteine proteinase consisting of a prodomain plus large and small catalytic subunits, that play a central role in cell apoptosis. Caspase 14 possesses an unusually short prodomain and is highly expressed in embryonic tissues but absent from most of the adult tissues except for the skin, which suggests a role in ontogenesis and skin physiology. Unlike the other short prodomain caspases(caspase-3, caspase-6, and caspase-7), Caspase 14 was not processed by multiple death stimuli including activation of members of the tumor necrosis factor receptor family and expression of proapaptotic members of the bcl-2 family. Caspase 14 has been described to be processed and activated by anti-Fas agonist antibody or TNF-related apoptosis inducing ligand in vivo. The expression and processing of this caspase may take part in keratinocyte terminal differentiation, which is essential for the skin barrier.

Caspase-14/CASP14 代替名

CASP14,MGC119079,CASP-14,Caspase-14,MGC119078, [human]
Casp14,CASP-14,MGC123948,MGC123949,MICE,mini-ICE,Caspase-14, [mouse]
MICE,mini-ICE, [mus-musculus]

Caspase-14/CASP14 関連研究

  • Hu SM, et al. (1998) Caspase-14 is a novel developmentally regulated protease. The journal of biological chemistry. 273: 29648-53.
  • Marc Van De Craen, et al. (1998) Identification of a new caspase homologue: caspase-14. Cell death differ. 5(10): 838-46.
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