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Caspase-14 / CASP14 抗体, ウサギモノクローナル抗体

データシートレビュー関連製品プロトコル
Human CASP14 抗体製品情報
免疫原:Recombinant Human Caspase-14 / CASP14 protein (Catalog#11856-H07E)
Clone ID:001
Ig タイプ:Rabbit IgG
濃度:
エンドトキシン:
製剤:0.2 μm filtered solution in PBS with 5% trehalose
調製:This antibody was obtained from a rabbit immunized with purified, recombinant Human Caspase-14 / CASP14 (rh Caspase-14 / CASP14; Catalog#11856-H07E; NP_036246.1; Ser2-Gln242).
Human CASP14 抗体使用ガイド
特異度:Human Caspase-14 / CASP14
アプリケーション:IHC-P

IHC-P: 1-10 μg/mL

保存:This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Human CASP14 Antibody IHC Application Image
Caspase-14 / CASP14 Antibody, Rabbit MAb, Immunohistochemistry
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Caption:
Immunochemical staining of human CASP14 in human skin with rabbit monoclonal antibody (5 µg/mL, formalin-fixed paraffin embedded sections).
Other CASP14 Antibody Products
Caspase-14/CASP14 背景

Caspase 14 is a member of the caspase family. Caspases are a kind of cysteine proteinase consisting of a prodomain plus large and small catalytic subunits, that play a central role in cell apoptosis. Caspase 14 possesses an unusually short prodomain and is highly expressed in embryonic tissues but absent from most of the adult tissues except for the skin, which suggests a role in ontogenesis and skin physiology. Unlike the other short prodomain caspases(caspase-3, caspase-6, and caspase-7), Caspase 14 was not processed by multiple death stimuli including activation of members of the tumor necrosis factor receptor family and expression of proapaptotic members of the bcl-2 family. Caspase 14 has been described to be processed and activated by anti-Fas agonist antibody or TNF-related apoptosis inducing ligand in vivo. The expression and processing of this caspase may take part in keratinocyte terminal differentiation, which is essential for the skin barrier.

Human Caspase-14/CASP14 参考文献
  • Hu SM, et al. (1998) Caspase-14 is a novel developmentally regulated protease. The journal of biological chemistry. 273: 29648-53.
  • Marc Van De Craen, et al. (1998) Identification of a new caspase homologue: caspase-14. Cell death differ. 5(10): 838-46.
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    カタログ: 11856-R001-50
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    注意:すべての製品は、"研究目的のみに使用するものであり、診断または治療目的に使用するものではありません"