CTLA-4 (タンパク質 | 抗体 | cDNA クローン | ELISA キット)

All CTLA-4 reagents are produced in house and quality controlled, including 17 CTLA-4 Antibody, 1 CTLA-4 ELISA, 30 CTLA-4 Gene, 1 CTLA-4 IP Kit, 16 CTLA-4 Lysate, 16 CTLA-4 Protein, 2 CTLA-4 qPCR. All CTLA-4 reagents are ready to use.

CTLA-4 Protein (16)

CTLA-4 Antibody (17)

CTLA-4 ELISA キット(すぐに使用できます)& ELISA抗体ペアセット(すぐに使用できません)(1)

CTLA-4 cDNA Clone (30)

NM_005214.3

クローニングベクター cDNA 製品

In lentiviral vector

NM_009843.3

クローニングベクター cDNA 製品

In lentiviral vector

NM_031674.1

クローニングベクター cDNA 製品

NM_001003106.1

クローニングベクター cDNA 製品

NM_001044739.1

In expression vector

In lentiviral vector

CTLA-4 Lysate (16)

CTLA-4 の背景知識

Cytotoxic T-lymphocyte protein 4, also known as CTLA4 and CD152, is a single-pass type I membrane protein and a member of the immunoglobulin superfamily. It is the second member of the CD28 receptor family. The ligands or counterreceptors for these two proteins are the B7 family members, CD8 (B7-1) and CD86 (B7-2). CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. Intracellular CTLA4 is also found in regulatory T cells and may play an important role in their functions. CD152 or cytotoxic T lymphocyte antigen-4 (CTLA-4) is an essential receptor involved in the negative regulation of T cell activation. Because of its profound inhibitory role, CD152 has been considered a sound susceptible candidate in autoimmunity and a persuasive target for cancer immunotherapy. In particular, recent evidence suggests that CD152 is also important in the homeostasis and function of a population of suppressive cells, termed regulatory T cells (Treg).

CTLA-4 の参考文献

  • Slavik JM, et al. (1999) CD28/CTLA-4 and CD80/CD86 families: signaling and function. Immunol Res. 19(1): 1-24.
  • Holmberg D, et al. (2005) CTLA-4 (CD152) and its involvement in autoimmune disease. Autoimmunity. 38(3): 225-33.
  • Chin LT, et al. (2008) Immune intervention with monoclonal antibodies targeting CD152 (CTLA-4) for autoimmune and malignant diseases. Chang Gung Med J. 31(1): 1-15.