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CSF1R / MCSF Receptor / CD115 抗体, ウサギポリクローナル抗体, Antigen Affinity Purified

  • CSF1R / MCSF Receptor / CD115 Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry
  • CSF1R / MCSF Receptor / CD115 Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry
データシートレビュー関連製品プロトコル
人々 CSF1R 抗体製品情報
免疫原:Recombinant Human CSF1R / M-CSFR / CD115 protein (Catalog#10161-H20B2)
Clone ID:
Ig タイプ:Rabbit IgG
濃度:
エンドトキシン:
製剤:0.2 μm filtered solution in PBS with 5% trehalose
調製:Produced in rabbits immunized with purified, recombinant Human CSF1R / M-CSFR / CD115 (rh CSF1R / M-CSFR / CD115; Catalog#10161-H20B2; NP_005202.2; Lys543-Asp922). CSF1R / M-CSFR / CD115 specific IgG was purified by Human CSF1R / M-CSFR / CD115 affinity chromatography.
人々 CSF1R Antibody IHC Application Image
CSF1R / MCSF Receptor / CD115 Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry
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Caption:
Immunochemical staining of human CSF1R in human kidney with rabbit polyclonal antibody (1 µg/mL, formalin-fixed paraffin embedded sections).
CSF1R / MCSF Receptor / CD115 Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry
[クリックして画像を拡大]
Caption:
Immunochemical staining of human CSF1R in human lung with rabbit polyclonal antibody (1 µg/mL, formalin-fixed paraffin embedded sections).
Other CSF1R Antibody Products
反応度: Human  
アプリケーション: 
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10161-T24-50
10161-T24-200
10161-T24-100
50 µg 
200 µg 
100 µg 
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反応度: Human  
アプリケーション: ELISA  
    10161-RP03-50
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    200 µg 
    100 µg 
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    アプリケーション: FCM  
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    10161-MM04-50
    10161-MM04-200
    10161-MM04-100
    50 µg 
    200 µg 
    100 µg 
    Add to Cart
    反応度: Human  
    アプリケーション: ELISA  
      10161-MM12-50
      10161-MM12-200
      10161-MM12-100
      50 µg 
      200 µg 
      100 µg 
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      反応度: Human  
      アプリケーション: ELISA  
        10161-RP01-400
        10161-RP01-200
        10161-RP01-100
        400 µg 
        200 µg 
        100 µg 
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        反応度: Human  
        アプリケーション: ELISA  
          10161-MM02-50
          10161-MM02-200
          10161-MM02-100
          50 µg 
          200 µg 
          100 µg 
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          反応度: Human  
          アプリケーション: ELISA  
            10161-R029-50
            10161-R029-100
            50 µg 
            100 µg 
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            反応度: Human  
            アプリケーション: FCM  
            • Slide 1
            10161-MM04-F-25
            10161-MM04-F-100
            25 Test 
            100 Tests 
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            反応度: Human  
            アプリケーション: ELISA  
              10161-R108-50
              10161-R108-100
              50 µg 
              100 µg 
              Add to Cart
              反応度: Mouse  
              アプリケーション: ELISA  
                50059-R220-50
                50059-R220-100
                50 µg 
                100 µg 
                Add to Cart
                反応度: Mouse  
                アプリケーション: ELISA  
                  50059-RP02-50
                  50059-RP02-200
                  50059-RP02-100
                  50 µg 
                  200 µg 
                  100 µg 
                  Add to Cart
                  反応度: Mouse  
                  アプリケーション: ELISA  
                  • Slide 1
                  50059-RP01-400
                  50059-RP01-200
                  50059-RP01-100
                  400 µg 
                  200 µg 
                  100 µg 
                  Add to Cart
                  反応度: Rat  
                  アプリケーション: ELISA  
                    80447-RP01-400
                    80447-RP01-200
                    80447-RP01-100
                    400 µg 
                    200 µg 
                    100 µg 
                    Add to Cart
                    反応度: Rat  
                    アプリケーション: ELISA  
                      80447-T16-50
                      80447-T16-200
                      80447-T16-100
                      50 µg 
                      200 µg 
                      100 µg 
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                      MCSF Receptor/CSF1R/CD115 背景

                      M-CSFR encoded by the proto-oncogene c-fms is the receptor for colony stimulating factor 1 (CSF1R), a cytokine involved in the proliferation, differentiation, and activation of macrophages. This cell surface glycoprotein is consisted by an extracellular ligand-binding domain, a single membrane-spanning segment, and an intracellular tyrosine kinase domain. Binding of CSF1 activates the receptor kinase, leading to "autophosphorylation" of receptor subunits and the concomitant phosphorylation of a series of cellular proteins on tyrosine residues. CSF1R is a tyrosine kinase receptor that is absolutely required for macrophage differentiation and thus occupies a central role in hematopoiesis. CSF1 and its receptor (CSF1R, product of c-fms proto-oncogene) were initially implicated as essential for normal monocyte development as well as for trophoblastic implantation. This apparent role for CSF1/CSF1R in normal mammary gland development is very intriguing because this receptor/ligand pair has also been found to be important in the biology of breast cancer in which abnormal expression of CSF1 and its receptor correlates with tumor cell invasiveness and adverse clinical prognosis. Tumor cell expression of CSF1R is under the control of several steroid hormones (glucocorticoids and progestins) and the binding of several bHLH transcription factors, while tumor cell expression of CSF-1 appears to be regulated by other hormones, some of which are involved in normal lactogenic differentiation. However, studies have demonstrated that CSF1 and CSF1R have additional roles in mammary gland development during pregnancy and lactation. The role of CSF1 and CSF1R in normal and neoplastic mammary development that may elucidate potential relationships of growth factor-induced biological changes in the breast during pregnancy and tumor progression.

                      人々 MCSF Receptor/CSF1R/CD115 参考文献
                    • Sherr CJ. (1990) The colony-stimulating factor 1 receptor: pleiotropy of signal-response coupling. Lymphokine Res. 9(4): 543-8.
                    • Kacinski BM. (1997) CSF-1 and its receptor in breast carcinomas and neoplasms of the female reproductive tract. Mol Reprod Dev. 46(1): 71-4.
                    • Sapi E, et al. (1999) The role of CSF-1 in normal and neoplastic breast physiology. Proc Soc Exp Biol Med. 220(1): 1-8.
                    • Sapi E. (2004) The role of CSF-1 in normal physiology of mammary gland and breast cancer: an update. Exp Biol Med (Maywood). 229(1): 1-11.
                    • Bonifer C, et al. (2008) The transcriptional regulation of the Colony-Stimulating Factor 1 Receptor (csf1r) gene during hematopoiesis. Front Biosci. 13: 549-60.
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                      Size / Price
                      カタログ: 10161-RP02-50
                      定価: 
                      価格:      (You Save: )

                      Datasheet & Documentation

                      All information of our products is subject to change without notice. Please refer to COA enclosed in shipped package for the newest information.
                      注意:すべての製品は、"研究目的のみに使用するものであり、診断または治療目的に使用するものではありません"