クイック注文

CDK8  Protein, Antibody, ELISA Kit, cDNA Clone

CDK8 Related Area

CDK8 関連経路

CDK8 サマリー & タンパク質情報

CDK8 背景

触媒活性: ATP + a protein = ADP + a phosphoprotein. {ECO:0000269|PubMed:10993082}.; ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate. {ECO:0000269|PubMed:10993082}.
補因子: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250};
サブユニット構造: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP. The cylin/CDK pair formed by CCNC/CDK8 also associates with the large subunit of RNA polymerase II. Interacts with CTNNB1, GLI3 and MAML1. {ECO:0000269|PubMed:10024883, ECO:0000269|PubMed:15175163, ECO:0000269|PubMed:15546612, ECO:0000269|PubMed:15989967, ECO:0000269|PubMed:17000779, ECO:0000269|PubMed:21806996, ECO:0000269|PubMed:9734358}.
細胞内位置: Nucleus {ECO:0000305}.
シーケンスの類似性: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. {ECO:0000305}.; Contains 1 protein kinase domain. {ECO:0000255|PROSITE-ProRule:PRU00159}.
General information above from UniProt

CDK8 代替名

K35, [homo-sapiens]

CDK8 関連研究

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