Anti-CDCP1 Antibody

Cat: 51110-RP02

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Anti-CDCP1 Antibody (Rabbit Polyclonal antibody) General Information

Product name
Anti-CDCP1 Antibody
Validated applications
ELISA,IHC-P
Species reactivity
Reacts with: Mouse
Specificity
Mouse CDCP1
Immunogen
Recombinant Mouse CDCP1 protein (Catalog#51110-M08H)
Preparation
Produced in rabbits immunized with purified, recombinant Mouse CDCP1 (rM CDCP1; Catalog#51110-M08H; Q5U462; Met1-Leu666). CDCP1 specific IgG was purified by Mouse CDCP1 affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A & Antigen Affinity
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

Anti-CDCP1 Antibody (Rabbit Polyclonal antibody) Validated Applications

Application Dilution Notes
ELISA 1:5000-1:10000  
IHC-P 1:500-1:2000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-CDCP1 Antibody (Rabbit Polyclonal antibody) Images

Mouse CDCP1 Immunohistochemistry(IHC) 3339
Immunochemical staining of mouse CDCP1 in mouse lung with rabbit polyclonal antibody (1:1000, formalin-fixed paraffin embedded sections). The left panel: tissue incubated with primary antibody; The right panel: tissue incubated with the mixture of primary antibody and antigen (recombinant protein).
Mouse CDCP1 Immunohistochemistry(IHC) 3340
Immunochemical staining of mouse CDCP1 in mouse intestine with rabbit polyclonal antibody (1:1000, formalin-fixed paraffin embedded sections). The left panel: tissue incubated with primary antibody; The right panel: tissue incubated with the mixture of primary antibody and antigen (recombinant protein).

Anti-CDCP1 Antibody Alternative Names

Anti-9030022E12Rik Antibody;Anti-AA409659 Antibody;Anti-E030027H19Rik Antibody

CDCP1 Background Information

CDCP1 contains three extracellular CUB domains. It is a putative stem cell marker that is highly expressed in some human cancer cells and in both, typical and atypical (cancerous) colons. It interacts with CDH2/N-cadherin, CDH3/P-cadherin, SDC1/syndecan-1, SDC4/syndecan-4 and the serine protease ST14/MT-SP1. It also interacts with SRC and PRKCG/protein kinase C gamma. CDCP1 is taken as a key regulator of EGF/EGFR-induced cell migration. It has been shown that signaling via EGF/EGFR induces migration of ovarian cancer Caov3 and OVCA420 cells with concomitant up-regulation of CDCP1 mRNA and protein. Consistent with a role in cell migration CDCP1 relocates from cell-cell junctions to punctate structures on filopodia after activation of EGFR. It may be involved in cell adhesion and cell matrix association. It also may play a role in the regulation of anchorage versus migration or proliferation versus differentiation via its phosphorylation. It has been taken as a novel marker for leukemia diagnosis and for immature hematopoietic stem cell subsets.

Full Name
CUB domain containing protein 1
References
  • Conze T, et al.. (2003) CDCP1 is a novel marker for hematopoietic stem cells. Ann N Y Acad Sci. 996 (1): 222-6.
  • Hooper JD, et al. (2003) Subtractive immunization using highly metastatic human tumor cells identifies SIMA135/CDCP1, a 135 kDa cell surface phosphorylated glycoprotein antigen. Oncogene. 22(12): 1783-94.
  • Scherl-Mostageer M, et al. (2001) Identification of a novel gene, CDCP1, overexpressed in human colorectal cancer. Oncogene. 20(32):4402-8.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-CDCP1 Antibody Rabbit Polyclonal ELISA 51110-RP01
    Anti-CDCP1 Antibody Rabbit Monoclonal ELISA(Cap) 51110-R001
    Anti-CDCP1 Antibody Rabbit Monoclonal ELISA 51110-R040
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