CDC37 (タンパク質 | 抗体 | cDNA クローン | ELISA キット)

All CDC37 reagents are produced in house and quality controlled, including 4 CDC37 Antibody, 30 CDC37 Gene, 3 CDC37 IP Kit, 3 CDC37 Lysate, 3 CDC37 Protein, 2 CDC37 qPCR. All CDC37 reagents are ready to use.

CDC37 Protein (3)

CDC37 Antibody (4)

CDC37 cDNA Clone (30)

NM_007065.3

クローニングベクター cDNA 製品

In lentiviral vector

NM_016742.4

クローニングベクター cDNA 製品

In lentiviral vector

CDC37 Lysate (3)

CDC37 関連の研究分野

CDC37 の背景知識

CDC37 is a protein that is expressed in proliferative zones during embryonic development and in adult tissues, consistent with a positive role in proliferation and is required for cell division in budding yeast. CDC37 is though to play an important role in the establishment of signaling pathways controlling cell proliferation through targeting intrinsically unstable oncoprotein kinases such as Cdk-4, Raf-1, and src to the molecular chaperone Hsp9. Decreased Hsp9 expression can reduce the levels of microtubule-associated protein tau, whose overexpression may induce many diseases. CDC37 is considered as a co-chaperone that is classified to Hsp9's accessory proteins. It has been reported that suppression of Cdc37 destabilized tau, leading to its clearance, whereas cdc37 overexpression preserved tau.Cdc37 was found to co-localize with tau in neuronal cells and to physically interact with tau from human brain. Moreover, Cdc37 levels significantly increased with age.

CDC37 の参考文献

  • Dai K, et al. (1996) P hysical Interaction of Mammalian CDC37 with CDK4. The journal of biological chemistry. 271: 22030-4.
  • Pearl LH, et al. (2005) Hsp90 and Cdc37-a chaperone cancer conspiracy. Current opinion in genetics development. 15 (1): 55-61.
  • Chen GQ, et al. (2002) TNF-Induced Recruitment and Activation of the IKK Complex Require Cdc37 and Hsp90. Molecular cell. 9 (2): 401-10.