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CDC37  Protein, Antibody, ELISA Kit, cDNA Clone

発現宿主: Baculovirus-Insect Cells  
10647-H09B-50
10647-H09B-20
50 µg 
20 µg 
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発現宿主: Baculovirus-Insect Cells  
50826-MNCB-20
50826-MNCB-100
20 µg 
100 µg 
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発現宿主: Baculovirus-Insect Cells  
50826-M20B-20
50826-M20B-100
20 µg 
100 µg 
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  • Slide 1

CDC37 Related Area

CDC37 関連経路

    CDC37 サマリー & タンパク質情報

    CDC37 背景

    遺伝子の概要: The protein encoded by this gene is highly similar to Cdc 37, a cell division cycle control protein of Sacchromyces cerevisiae. This protein is a molecular chaperone with specific function in cell signal transduction. It has been shown to form complex with Hsp90 and a variety of protein kinases including CDK4, CDK6, SRC, RAF-1, MOK, as well as eIF2 alpha kinases. It is thought to play a critical role in directing Hsp90 to its target kinases.
    General information above from NCBI
    サブユニット構造: Forms a complex with Hsp90/HSP90AB1 and CDK6. Interacts with AR, CDK4, CDK6, EIF2AK1 and RB1. {ECO:0000269|PubMed:11036079, ECO:0000269|PubMed:11085988, ECO:0000269|PubMed:9150368, ECO:0000269|PubMed:9482106}.
    細胞内位置: Cytoplasm {ECO:0000269|PubMed:9482106}.
    翻訳後: Constitutively sumoylated by UBE2I. {ECO:0000269|PubMed:17709345}.
    シーケンスの類似性: Belongs to the CDC37 family. {ECO:0000305}.
    General information above from UniProt

    CDC37 is a protein that is expressed in proliferative zones during embryonic development and in adult tissues, consistent with a positive role in proliferation and is required for cell division in budding yeast. CDC37 is though to play an important role in the establishment of signaling pathways controlling cell proliferation through targeting intrinsically unstable oncoprotein kinases such as Cdk-4, Raf-1, and src to the molecular chaperone Hsp90. Decreased Hsp90 expression can reduce the levels of microtubule-associated protein tau, whose overexpression may induce many diseases. CDC37 is considered as a co-chaperone that is classified to Hsp90's accessory proteins. It has been reported that suppression of Cdc37 destabilized tau, leading to its clearance, whereas cdc37 overexpression preserved tau.Cdc37 was found to co-localize with tau in neuronal cells and to physically interact with tau from human brain. Moreover, Cdc37 levels significantly increased with age.

    CDC37 代替名

    P50CDC37, [homo-sapiens]
    CDC37,P50CDC37, [human]
    Cdc37,p50,p50Cdc37, [mouse]
    p50,p50Cdc37, [mus-musculus]

    CDC37 関連研究

  • Dai K, et al. (1996) P hysical Interaction of Mammalian CDC37 with CDK4. The journal of biological chemistry. 271: 22030-4.
  • Pearl LH, et al. (2005) Hsp90 and Cdc37-a chaperone cancer conspiracy. Current opinion in genetics development. 15 (1): 55-61.
  • Chen GQ, et al. (2002) TNF-Induced Recruitment and Activation of the IKK Complex Require Cdc37 and Hsp90. Molecular cell. 9 (2): 401-10.
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