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CD98/SLC3A2/4F2HC  Protein, Antibody, ELISA Kit, cDNA Clone

発現宿主: Human Cells  
  • Slide 1
12206-H07H-50
12206-H07H-100
50 µg 
100 µg 
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発現宿主: Human Cells  
  • Slide 1
50813-M07H-20
50813-M07H-50
20 µg 
50 µg 
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発現宿主: Human Cells  
  • Slide 1
80339-R01H-100
80339-R01H-20
100 µg 
20 µg 
Add to Cart
発現宿主: Human Cells  
  • Slide 1
80339-R07H-20
80339-R07H-100
20 µg 
100 µg 
Add to Cart

CD98/SLC3A2/4F2HC 関連経路

    CD98/SLC3A2/4F2HC サマリー & タンパク質情報

    CD98/SLC3A2/4F2HC 背景

    遺伝子の概要: This SLC3A2 gene is a member of the solute carrier family and encodes a cell surface, transmembrane protein. CD98 exists as the heavy chain of a heterodimer, covalently bound through di-sulfide bonds to one of several possible light chains. CD98 plays a role in regulation of intracellular calcium levels and transports L-type amino acids. Alternatively spliced transcript variants, encoding different isoforms, have been characterized. [provided by RefSeq, Nov 2010]
    General information above from NCBI
    サブユニット構造: Disulfide-linked heterodimer of a glycosylated heavy chain and a non-glycosylated light chain (SLC7A5, SLC7A6, SLCA7A7, SLC7A8, SLC7A10 or SLCA7A11). Colocalizes with cadherins (By similarity). Interacts with FAM57A/CT120 and ICAM1. Constitutively and specifically associates with beta-1 integrins (alpha-2/beta-1, alpha-3/beta-1, alpha-5/beta-1 and alpha-6/beta-1), but minimally with alpha-4/beta-1.
    細胞内位置: Apical cell membrane; Single-pass type II membrane protein. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Localized to the plasma membrane when associated with SLC7A5 or SLC7A8. Localized to the placental apical membrane. Located selectively at cell-cell adhesion sites (By similarity). Colocalized with SLC7A8/LAT2 at the basolateral membrane of kidney proximal tubules and small intestine epithelia. Expressed in both luminal and abluminal membranes of brain capillary endothelial cells (By similarity).
    組織特異性: Expressed ubiquitously in all tissues tested with highest levels detected in kidney, placenta and testis and weakest level in thymus. During gestation, expression in the placenta was significantly stronger at full-term than at the mid- trimester stage. Expressed in HUVECS and at low levels in resting peripheral blood T-lymphocytes and quiescent fibroblasts. Also expressed in fetal liver and in the astrocytic process of primary astrocytic gliomas. Expressed in retinal endothelial cells and in the intestinal epithelial cell line C2BBe1.
    誘導: Expression is induced in resting peripheral blood T- lymphocytes following PHA stimulation. Expression increases at the time of maximal DNA synthesis, in fibroblasts stimulated to divide. Expression and the uptake of leucine is stimulated in mononuclear, cytotrophoblast-like choriocarcinoma cells by combined treatment with PMA and calcium ionophore.
    翻訳後: Phosphorylation on Ser-406; Ser-408 or Ser-410 and on Ser-527 or Ser-531 by ecto-protein kinases favors heterotypic cell-cell interactions.
    シーケンスの類似性: Belongs to the SLC3A transporter family.C
    General information above from UniProt

    4F2 cell-surface antigen heavy chain, also known as 4F2 heavy chain antigen, Lymphocyte activation antigen 4F2 large subunit, CD98, SLC3A2 and MDU1, is a single-pass type I I membrane protein which belongs to the SLC3A transporter family. SLC3A2 / MDU1 is expressed ubiquitously in all tissues tested with highest levels detected in kidney, placenta and testis and weakest level in thymus. During gestation, expression in the placenta is significantly stronger at full-term than at the mid-trimester stage. SLC3A2 / MDU1 is expressed in HUVECS and at low levels in resting peripheral blood T-lymphocytes and quiescent fibroblasts. It is expressed in fetal liver and in the astrocytic process of primary astrocytic gliomas. SLC3A2 / MDU1 is also expressed in retinal endothelial cells and in the intestinal epithelial cell line Caco2-BBE. SLC3A2 / MDU1 is required for the function of light chain amino-acid transporters. It involved in sodium-independent, high-affinity transport of large neutral amino acids such as phenylalanine, tyrosine, leucine, arginine and tryptophan. SLC3A2 / MDU1 is involved in guiding and targeting of LAT1 and LAT2 to the plasma membrane. When associated with SLC7A6 or SLC7A7, SLC3A2 / MDU1 acts as an arginine/glutamine exchanger, following an antiport mechanism for amino acid transport, influencing arginine release in exchange for extracellular amino acids. SLC3A2 / MDU1 plays a role in nitric oxide synthesis in human umbilical vein endothelial cells (HUVECs) via transport of L-arginine. It is required for normal and neoplastic cell growth. When associated with SLC7A5/LAT1, SLC3A2 / MDU1 is also involved in the transport of L-DOPA across the blood-brain barrier, and that of thyroid hormones triiodothyronine (T3) and thyroxine (T4) across the cell membrane in tissues such as placenta.

    CD98/SLC3A2/4F2HC 代替名

    4F2,CD98,MDU1,4F2HC,4T2HC,NACAE,CD98HC, [homo-sapiens]
    MDU1,NACAE,SLC3A2,4F2,4F2HC,4T2HC,CD98,CD98HC, [human]
    AI314110,NACAE,Slc3a2,4F2,4F2HC,Cd98,Ly10,Ly-10,Ly-m10,Mdu1,Mgp-2hc, [mouse]
    4F2,Cd98,Ly10,Mdu1,4F2HC,Ly-10,NACAE,Ly-m10,Mgp-2hc,AI314110, [mus-musculus]

    CD98/SLC3A2/4F2HC 関連研究

  • Torrents D. et al., 1998, J Biol Chem. 273: 32437-45.
  • Pfeiffer R. et al., 1999, EMBO J. 18: 49-57.
  • Broeer A. et al., 2000, Biochem J. 349: 787-95.
  • Yanagida O. et al., 2001, Biochim Biophys Acta. 1514: 291-302.
  • Broeer A. et al., 2001, Biochem J. 355: 725-31.
  • Fort J. et al., 2007, J Biol Chem. 282: 31444-52.
  • Mayya V. et al., 2009, Sci Signal. 2: RA46-RA46.
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