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CD93/C1qR  Protein, Antibody, ELISA Kit, cDNA Clone

発現宿主: Human Cells  
12589-H02H-50
12589-H02H-20
50 µg 
20 µg 
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発現宿主: Human Cells  
12589-H08H-50
12589-H08H-20
50 µg 
20 µg 
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発現宿主: Human Cells  
80207-R08H-50
80207-R08H-200
50 µg 
200 µg 
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CD93/C1qR Related Area

CD93/C1qR 関連経路

    CD93/C1qR サマリー & タンパク質情報

    CD93/C1qR 背景

    遺伝子の概要: The protein encoded by this CD93 gene is a cell-surface glycoprotein and type I membrane protein that was originally identified as a myeloid cell-specific marker. CD93 was once thought to be a receptor for C1q, but now is thought to instead be involved in intercellular adhesion and in the clearance of apoptotic cells. The intracellular cytoplasmic tail of CD93 has been found to interact with moesin, a protein known to play a role in linking transmembrane proteins to the cytoskeleton and in the remodelling of the cytoskeleton.
    General information above from NCBI
    サブユニット構造: Interacts with HCV core protein. Interacts with C1QBP; the association may represent a cell surface C1q receptor. {ECO:0000269|PubMed:11086025, ECO:0000269|PubMed:9233640}.
    細胞内位置: Membrane; Single-pass type I membrane protein.
    組織特異性: Highly expressed in endothelial cells, platelets, cells of myeloid origin, such as monocytes and neutrophils. Not expressed in cells of lymphoid origin.
    翻訳後: N- and O-glycosylated. {ECO:0000269|PubMed:10092817}.
    シーケンスの類似性: Contains 1 C-type lectin domain. {ECO:0000255|PROSITE-ProRule:PRU00040}.; Contains 5 EGF-like domains. {ECO:0000255|PROSITE-ProRule:PRU00076}.
    General information above from UniProt

    CD93 or C1q receptor 1 (C1qR) is an about 120 kDa O-sialoglycoprotein that within the hematopoietic system is selectively expressed on cells of the myeloid lineage. CD93/C1qR is a highly glycosylated transmembrane protein expressed on monocytes, neutrophils, endothelial cells, and stem cells. CD93 was originally identified as a myeloid cell-surface marker and subsequently associated with an ability to modulate phagocytosis of suboptimally opsonized immunoglobulin G and complement particles in vitro. CD93/C1qR, a receptor expressed during early B-cell development, is reinduced during plasma-cell differentiation. High CD93/CD138 expression was restricted to antibody-secreting cells both in T-dependent and T-independent responses as naive, memory, and germinal-center B cells remained CD93-negative. CD93 was expressed on (pre)plasmablasts/plasma cells, including long-lived plasma cells that showed decreased cell cycle activity, high levels of isotype-switched Ig secretion, and modification of the transcriptional network. CD93 is important for the maintenance of plasma cells in bone marrow niches.

    CD93/C1qR 代替名

    C1QR1,C1qRP,CDw93,ECSM3,MXRA4,C1qR(P),dJ737E23.1, [homo-sapiens]
    C1qR,C1qR(P),C1qRP,CD93,MXRA4,C1QR1,CDw93,dJ737E23.1,ECSM3, [human]
    6030404G09Rik,AA145088,AA4.1,AW555904,C1qR,C1qr1,Cd93,Ly68,RP23-70N3.4,C1qrp, [mouse]
    Ly68,AA4.1,C1qr1,C1qrp,AA145088,AW555904,6030404G09Rik, [mus-musculus]

    CD93/C1qR 関連研究

  • Bohlson SS, et al. (2005) CD93 is rapidly shed from the surface of human myeloid cells and the soluble form is detected in human plasma. J Immunol. 175(2): 1239-47.
  • Norsworthy PJ, et al. (2004) Murine CD93 (C1qRp) contributes to the removal of apoptotic cells in vivo but is not required for C1q-mediated enhancement of phagocytosis. J Immunol. 172(6): 3406-14.
  • Chevrier S, et al. (2009) CD93 is required for maintenance of antibody secretion and persistence of plasma cells in the bone marrow niche. Proc Natl Acad Sci U S A. 106(10): 3895-900.
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