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All CD89 reagents are produced in house and quality controlled, including 12 CD89 Antibody, 1 CD89 ELISA, 26 CD89 Gene, 2 CD89 Lysate, 2 CD89 Protein, 2 CD89 qPCR. All CD89 reagents are ready to use.
Recombinant CD89 proteins are expressed by HEK293 Cells with fusion tags as C-His.
CD89antibodies are validated with different applications, which are ELISA, FCM, ELISA(Cap).
CD89cDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each CD89 of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.
CD89ELISA Kit are quality controlled by 8 internation QC standard which guarantee every ELISA Kit with high quality.
FCAR, also called FcαRI or CD89, is a type I transmembrane receptor for Fc region of IgA which is the most abundant immunoglobulin in mucosal areas but is only the second most common antibody isotype in serum. This receptor is present on the surface of myeloid lineage cells such as neutrophils, monocytes, macrophages, and eosinophils, especially phagocytes located in mucosal areas. Upon ligand IgA binding, FcαRI associates with the FcR γ signaling molecule bearing the immunoreceptor tyrosine-based activation motif (ITAM) through a unique charge-based mechanism and triggers multiple cell-mediated immune responses. It has been reported that Fc RI is a dual-function receptor that can mediate both inflammatory and anti-inflammatory responses depending on the type of interaction with its ligand. Sustained aggregation of FCAR results in activation of target-cell functions such as antigen presentation and cytokine release. In contrast, Monomeric targeting with serum IgA or with a variety of anti-FcαRI Fab fragments triggers an inhibitory response and additionally induces apoptosis. FcαRI thus play an fundamental role in preventing tumor development and growth, as well as in controlling inflammation.
