All CD74 reagents are produced in house and quality controlled, including 11 CD74 Antibody, 54 CD74 Gene, 1 CD74 IPKit, 1 CD74 Lysate, 1 CD74 Protein, 2 CD74 qPCR. All CD74 reagents are ready to use.
Recombinant CD74 proteins are expressed by HEK293 Cells with fusion tags as N-His.
CD74antibodies are validated with different applications, which are ELISA, IHC-P, WB, IP, FCM.
CD74cDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each CD74 of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.
The cluster of differentiation (CD) system is commonly used as cell markers in immunophynotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules which associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins do not take part in cell signal process but have other functions such as cell adhesion. CD74, also known as HLA class2 histocompatibility antigen gamma chain and HLA-DR antigens-associated invariant chain, is a polypeptide involved in the formation and transport of MHC class2 protein. CD74 is expressed by B cells, macrophages, and Reed-Sternberg cells. When MHC class 2 protein was in the rough ER, its peptide-binding cleft was blocked by CD74 to prevent it from interacting with the endogenous peptides. CD74 also serves to facilitate MHC class2's export from ER.