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CD62L/L-Selectin  タンパク質

All CD62L Reagents

製品の説明: Active  
発現宿主: Human Cells  
11838-H08H-200
11838-H08H-100
200 µg 
100 µg 
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製品の説明: Active  
発現宿主: Human Cells  
50045-M03H-200
50045-M03H-100
200 µg 
100 µg 
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発現宿主: Human Cells  
50045-M08H-200
50045-M08H-100
200 µg 
100 µg 
Add to Cart
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製品の説明: Active  
発現宿主: Human Cells  
90168-C08H-200
90168-C08H-100
200 µg 
100 µg 
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製品の説明: Active  
発現宿主: Human Cells  
90168-C02H-200
90168-C02H-100
200 µg 
100 µg 
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  • Slide 1
発現宿主: Human Cells  
90169-C08H-200
90169-C08H-100
200 µg 
100 µg 
Add to Cart
  • Slide 1

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CD62L/L-Selectin Related Area

CD62L/L-Selectin 関連経路

    CD62L/L-Selectin サマリー & タンパク質情報

    CD62L/L-Selectin 背景

    遺伝子の概要: This SELL gene encodes a cell surface adhesion molecule that belongs to a family of adhesion/homing receptors. CD62L contains a C-type lectin-like domain, a calcium-binding epidermal growth factor-like domain, and two short complement-like repeats. The SELL gene product is required for binding and subsequent rolling of leucocytes on endothelial cells, facilitating their migration into secondary lymphoid organs and inflammation sites. Single-nucleotide polymorphisms in this gene have been associated with various diseases including immunoglobulin A nephropathy. Alternatively spliced transcript variants have been found for this SELL gene.
    General information above from NCBI
    サブユニット構造: Interaction with PSGL1/SELPLG and PODXL2 is required for promoting recruitment and rolling of leukocytes. This interaction is dependent on the sialyl Lewis X glycan modification of PSGL1 and PODXL2, and tyrosine sulfation modifications of PSGL1. Sulfation on 'Tyr-51' of PSGL1 is important for L-selectin binding.
    細胞内位置: Membrane; Single-pass type I membrane protein.
    組織特異性: Expressed in B-cell lines and T-lymphocytes. {ECO:0000269|PubMed:2473156}.
    シーケンスの類似性: Belongs to the selectin/LECAM family. {ECO:0000305}.; Contains 1 C-type lectin domain. {ECO:0000255|PROSITE-ProRule:PRU00040}.; Contains 1 EGF-like domain. {ECO:0000255|PROSITE-ProRule:PRU00076}.; Contains 2 Sushi (CCP/SCR) domains. {ECO:0000255|PROSITE-ProRule:PRU00302}.
    General information above from UniProt

    L-selectin (SELL), also known as CD62L, is a key adhesion molecule that regulates both the migration of leukocytes at sites of inflammation and the recirculation of lymphocytes between blood and lymphoid tissues. It belongs to the selectin family of proteins, and consisting of a large, highly glycosylated, extracellular domain, a single spanning transmembrane domain and a small cytoplasmic tail. L-selectin is the only selectin expressed on leukocytes and mediates a number of leukocyte-endothelial interactions. L-selectin acts as a "homing receptor" for leukocytes to enter secondary lymphoid tissues via high endothelial venules. Ligands present on endothelial cells will bind to leukocyte expressing L-selectin, slowing leukocyte trafficking through the blood, and facilitating entry into a secondary lymphoid organ at that point. L-selectin-mediated lymphocyte recirculation is required for maintaining the appropriate tissue distribution of lymphocyte subpopulations including naïve and effector subsets such as regulatory T cells. In addition, L-selectin-mediated entry into peripheral lymph nodes is required for optimal induction of lymphocyte homeostatic proliferation during lymphopenia. Importantly, L-selectin has been shown to have both adhesive and signaling functions during leukocyte migration. L-selectin has also been shown to mediate leukocyte recruitment during chronic inflammatory and autoimmune diseases and thus is a potential therapeutic target for drug development.

    CD62L/L-Selectin 代替名

    CD62L/L-Selectin 関連研究

  • Smalley DM, et al. (2005) L-selectin: mechanisms and physiological significance of ectodomain cleavage. J Cell Mol Med. 9(2): 255-66.
  • Grailer JJ, et al. (2009) L-selectin: role in regulating homeostasis and cutaneous inflammation. J Dermatol Sci. 56(3): 141-7.
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