All CD59 reagents are produced in house and quality controlled, including 24 CD59 Antibody, 2 CD59 ELISA, 41 CD59 Gene, 1 CD59 IPKit, 4 CD59 Lysate, 4 CD59 Protein, 2 CD59 qPCR. All CD59 reagents are ready to use.
Recombinant CD59 proteins are expressed by HEK293 Cells with fusion tags as C-human IgG1-Fc, C-His.
CD59antibodies are validated with different applications, which are WB, ELISA, IP, FCM, ELISA(Cap), ELISA(Det).
CD59cDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each CD59 of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.
CD59ELISA Kit are quality controlled by 8 internation QC standard which guarantee every ELISA Kit with high quality.
CD59 glycoprotein, also known as 20 kDa homologous restriction factor, HRF20, MAC-inhibitory protein, Membrane attack complex inhibition factor, Membrane inhibitor of reactive lysis, MIC11, MIRL and CD59, is a cell membrane protein which contains one UPAR/Ly6 domain. CD59 is a small, highly glycosylated, GPI-linked protein, with a wide expression profile. The soluble form of CD59 from urine retains its specific complement binding activity, but exhibits greatly reduced ability to inhibit MAC assembly on cell membranes. CD59 is a potent inhibitor of the complement membrane attack complex (MAC) action. CD59 was first identified as a regulator of the terminal pathway of complement. It acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. CD59 is involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase. Defects in CD59 are the cause of CD59 deficiency (CD59D).