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CD47  タンパク質

All CD47 Reagents

発現宿主: Human Cells  
12283-HCCH-50
12283-HCCH-100
50 µg 
100 µg 
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発現宿主: Human Cells  
12283-H02H-50
12283-H02H-100
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100 µg 
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発現宿主: Human Cells  
57231-M08H-50
57231-M08H-200
50 µg 
200 µg 
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発現宿主: Human Cells  
80305-R08H-50
80305-R08H-100
50 µg 
100 µg 
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発現宿主: Human Cells  
80305-R02H-50
80305-R02H-100
50 µg 
100 µg 
Add to Cart
  • Slide 1

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CD47 Related Area

CD47 関連経路

    CD47 サマリー & タンパク質情報

    CD47 背景

    遺伝子の概要: CD47 gene encodes a membrane protein, which is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to extracellular matrix. The encoded protein is also a receptor for the C-terminal cell binding domain of thrombospondin, and it may play a role in membrane transport and signal transduction. CD47 gene has broad tissue distribution, and is reduced in expression on Rh erythrocytes. Alternatively spliced transcript variants have been found for CD47 gene. [provided by RefSeq, Jul 2010]
    General information above from NCBI
    サブユニット構造: Interacts with THBS1 and fibrinogen (By similarity). Monomer. Interacts with SIRPA, SIRPG, UBQLN1 and UBQLN2. {ECO:0000250, ECO:0000269|PubMed:10549293, ECO:0000269|PubMed:11509594, ECO:0000269|PubMed:15383453, ECO:0000269|PubMed:18657508}.
    細胞内位置: Cell membrane {ECO:0000269|PubMed:7691831}; Multi-pass membrane protein {ECO:0000269|PubMed:7691831}.
    組織特異性: Very broadly distributed on normal adult tissues, as well as ovarian tumors, being especially abundant in some epithelia and the brain.
    シーケンスの類似性: Contains 1 Ig-like V-type (immunoglobulin-like) domain. {ECO:0000305}.
    General information above from UniProt

    CD47 contains 1 Ig-like V-type (immunoglobulin-like) domain and is a receptor for the C-terminal cell binding domain of thrombospondin. It may play a role in membrane transport and signal transduction. CD47 is also a membrane protein, which is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to extracellular matrix. It is very broadly distributed on normal adult tissues, as well as ovarian tumors, being especially abundant in some epithelia and the brain. CD47 may play a role in membrane transport and/or integrin dependent signal transduction. It may prevent premature elimination of red blood cells. It also may be involved in membrane permeability changes induced following virus infection. By acting as an adhesion receptor for THBS1 on platelets, CD47 plays a role in both cell adhesion and in the modulation of integrins. It also plays an important role in memory formation and synaptic plasticity in the hippocampus.

    Immune Checkpoint
    Immune Checkpoint Detection: Antibodies   Immune Checkpoint Detection: ELISA Antibodies   Immune Checkpoint Detection: WB Antibodies
    Immune Checkpoint Targets   Co-inhibitory Immune Checkpoint Targets

    Immunotherapy   Cancer Immunotherapy   Targeted Therapy

    CD47 代替名

    IAP,OA3,MER6, [homo-sapiens]
    antigen identified by monoclonal antibody 1D8,antigenic surface determinant protein OA3,CD47 antigen (Rh-related antigen,CD47 glycoprotein,IAP,integrin associated protein,integrin-associated signal transducer,integrin-associated signal transducer),leukocyte surface antigen CD47,MER6,OA3,Rh-related antigen, [human]
    9130415E20Rik,AA407862,AI848868,AW108519,B430305P08Rik,IAP,integrin-associated protein,Itgp,leukocyte surface antigen CD47,Rh-related antigen, [mouse]
    IAP,Itgp,AA407862,AI848868,AW108519,9130415E20Rik,B430305P08Rik, [mus-musculus]

    CD47 関連研究

  • Brown EJ, et al. (2001) Integrin-associated protein (CD47) and its ligands. Trends Cell Biol. 11(3): 130-5.
  • Oldenborg PA. (2004) Role of CD47 in erythroid cells and in autoimmunity. Leuk Lymphoma. 45(7): 1319-27.
  • Kaczorowski DJ, et al. (2007) Targeting CD47: NO limit on therapeutic potential. Circ Res. 100(5): 602-3.
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