All CD46 reagents are produced in house and quality controlled, including 8 CD46 Antibody, 29 CD46 Gene, 1 CD46 IPKit, 1 CD46 Lysate, 1 CD46 Protein, 1 CD46 qPCR. All CD46 reagents are ready to use.
Recombinant CD46 proteins are expressed by HEK293 Cells with fusion tags as C-His.
CD46antibodies are validated with different applications, which are ELISA, IHC-P, FCM, ICC/IF, IF, WB, IP.
CD46cDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each CD46 of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.
CD46, also known as Membrane Cofactor Protein (MCP), is a complement regulatory protein. CD46 is a type 1 membrane protein that plays an important inhibitory role in the complement system. CD46 is expressed in white blood cells, platelets, epithelial cells, and fibroblasts. Human CD46 shares 50% amino acid sequence identity with mouse and rat CD46. The importance of CD46 to complement regulation is underscored by the observation that genetic loss of CD46 leads to development of atypical hemolytic-uremic syndrome (aHUS), a disease characterized by uncontrolled complement activation. CD46 is implicated in the development and/or progression of selected cancer types.