CD40 (タンパク質 | 抗体 | cDNA クローン | ELISA キット)

All CD40 reagents are produced in house and quality controlled, including 27 CD40 Antibody, 2 CD40 ELISA, 40 CD40 Gene, 1 CD40 IP Kit, 14 CD40 Lysate, 17 CD40 Protein, 3 CD40 qPCR. All CD40 reagents are ready to use.

CD40 Protein (17)

CD40 Antibody (27)

CD40 ELISA キット(すぐに使用できます)& ELISA抗体ペアセット(すぐに使用できません)(2)

CD40 cDNA Clone (40)

NM_001250.4

クローニングベクター cDNA 製品

In lentiviral vector

NM_152854.2

In lentiviral vector

NM_134360.1

クローニングベクター cDNA 製品

In lentiviral vector

XM_001104333.2

クローニングベクター cDNA 製品

In lentiviral vector

CD40 Lysate (14)

CD40 の背景知識

CD40, also known as TNFRSF5, is a member of the TNF receptor superfamily which are single transmembrane-spanning glycoproteins. CD40 protein plays an essential role in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. CD40 protein is expressed in B cells, dendritic cells, macrophages, endothelial cells, and several tumor cell lines. Defects in CD40 result in hyper-IgM immunodeficiency type 3 (HIGM3). In addition, CD40/CD40L interaction is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis.

CD40 の参考文献

  • van Kooten C, et al. (2000). CD40-CD40 ligand. J Leukoc Biol. 67 (1): 2-17.
  • Bhushan A, et al. (2002). CD40:CD40L interactions in X-linked and non-X-linked hyper-IgM syndromes. Immunol Res. 24 (3): 311-24.
  • Chatzigeorgiou A, et al. (2009) CD40/CD40L signaling and its implication in health and disease. Biofactors. 35(6): 474-83.
  • Li R, et al. (2009) Expression of CD40 and CD40L in Gastric Cancer Tissue and Its Clinical Significance. Int J Mol Sci. 10(9): 3900-17.
  • Lievens D, et al. (2009) The multi-functionality of CD40L and its receptor CD40 in atherosclerosis. Thromb Haemost. 102(2): 206-14.