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CD38/ADPRC1  Protein, Antibody, ELISA Kit, cDNA Clone

発現宿主: Human Cells  
  • Slide 1
10818-H08H-10
10818-H08H-20
10818-H08H-50
10 µg 
20 µg 
50 µg 
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発現宿主: Human Cells  
  • Slide 1
10818-H32H-10
10818-H32H-20
10818-H32H-50
10 µg 
20 µg 
50 µg 
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発現宿主: Human Cells  
  • Slide 1
50191-M08H-10
50191-M08H-20
50191-M08H-50
10 µg 
20 µg 
50 µg 
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発現宿主: Human Cells  
  • Slide 1
80229-R02H-10
80229-R02H-20
10 µg 
20 µg 
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発現宿主: Human Cells  
  • Slide 1
80229-R08H-10
80229-R08H-20
10 µg 
20 µg 
Add to Cart
発現宿主: Human Cells  
  • Slide 1
90050-C02H-10
90050-C02H-20
90050-C02H-50
10 µg 
20 µg 
50 µg 
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発現宿主: Human Cells  
  • Slide 1
90050-C08H-10
90050-C08H-20
10 µg 
20 µg 
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発現宿主: Human Cells  
  • Slide 1
65003-T08H-10
65003-T08H-20
10 µg 
20 µg 
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CD38/ADPRC1 関連経路

CD38/ADPRC1 サマリー & タンパク質情報

CD38/ADPRC1 背景

遺伝子の概要: CD38 is a novel multifunctional ectoenzyme widely expressed in cells and tissues especially in leukocytes. CD38 also functions in cell adhesion,signal transduction and calcium signaling.
General information above from NCBI
触媒活性: NAD(+) + H(2)O = ADP-ribose + nicotinamide.
酵素調節: ATP inhibits the hydrolyzing activity.
細胞内位置: Membrane; Single-pass type II membrane protein.
組織特異性: Expressed at high levels in pancreas, liver, kidney, brain, testis, ovary, placenta, malignant lymphoma and neuroblastoma.
発生段階: Preferentially expressed at both early and late stages of the B and T-cell maturation. It is also detected on erythroid and myeloid progenitors in bone marrow, where the level of surface expression was shown to decrease during differentiation of blast-forming unit E to colony-forming unit E.
シーケンスの類似性: Belongs to the ADP-ribosyl cyclase family.
General information above from UniProt

The cluster of differentiation (CD) system is commonly used as cell markers in immunophynotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules which associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins do not take part in cell signal process but have other functions such as cell adhesion. Cluster of differentiation 38 (CD38), also known as ADP-ribosyl cyclase, is a glycoprotein found on the surface of many immune cells (white blood cells), including CD4+, CD8+, B and natural killer cells. It shares several characteristics with ADP-ribosyl cyclase 2 CD157. CD38 is a multifunctional ectoenzyme that catalyzes the synthesis and hydrolysis of cyclic ADP-ribose (cADPR) from NAD+ to ADP-ribose. It also functions in cell adhesion, signal transduction and calcium signaling. CD38 has been used as a prognostic marker in leukemia. It can also be used to identify plasma cells.

CD38/ADPRC1 代替名

T10,ADPRC1, [homo-sapiens]
CD38,T10, [human]
CD38,Cd38-rs1, [mouse]
ADPRC1,Cd38-rs1, [mus-musculus]

CD38/ADPRC1 関連研究

  • Zola H, et al. (2007) CD molecules 2006-human cell differentiation molecules. J Immunol Methods. 318 (1-2): 1-5.
  • Ho IC, et al. (2009) GATA3 and the T-cell lineage: essential functions before and after T-helper-2-cell differentiation. Nat Rev Immunol. 9 (2): 125-35.
  • Matesanz-Isabel J, et al. (2011) New B-cell CD molecules. Immunology Letters.134 (2): 104-12.
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