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CD33/Siglec-3  Protein, Antibody, ELISA Kit, cDNA Clone

発現宿主: Human Cells  
  • Slide 1
12238-H05H-50
12238-H05H-100
50 µg 
100 µg 
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発現宿主: Human Cells  
  • Slide 1
12238-HCCH-200
12238-HCCH-50
200 µg 
50 µg 
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発現宿主: Human Cells  
  • Slide 1
12238-H08H-50
12238-H08H-100
50 µg 
100 µg 
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発現宿主: Human Cells  
  • Slide 1
50712-MCCH-50
50712-MCCH-200
50 µg 
200 µg 
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発現宿主: Human Cells  
  • Slide 1
50712-M02H-50
50712-M02H-100
50 µg 
100 µg 
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発現宿主: Human Cells  
  • Slide 1
50712-M08H-20
50712-M08H-50
20 µg 
50 µg 
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CD33/Siglec-3 関連経路

    CD33/Siglec-3 サマリー & タンパク質情報

    CD33/Siglec-3 背景

    サブユニット構造: Interacts with PTPN6/SHP-1 and PTPN11/SHP-2 upon phosphorylation.
    ドメイン: Contains 2 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2- containing phosphatases.
    細胞内位置: Cell membrane; Single-pass type I membrane protein.
    組織特異性: Monocytic/myeloid lineage cells.
    翻訳後: Phosphorylation of Tyr-340 is involved in binding to PTPN6 and PTPN11. Phosphorylation of Tyr-358 is involved in binding to PTPN6.
    シーケンスの類似性: Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.
    Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
    Contains 1 Ig-like V-type (immunoglobulin-like) domain.
    General information above from UniProt

    Myeloid cell surface antigen CD33 also known as Sialic acid binding Ig-like lectin 3, CD33 antigen or Siglec-3, is a member of the immunoglobulin superfamily and SIGLEC (sialic acid binding Ig-like lectin) family. This Single-pass type I membrane protein contains 1 Ig-like C2-type (immunoglobulin-like) domain and 1 Ig-like V-type (immunoglobulin-like) domain. CD33 /Siglec-3 is a putative adhesion molecule of myelomonocytic-derived cells that mediates sialic-acid dependent binding to cells. CD33 /Siglec-3 preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. CD33/Siglec-3 induces apoptosis in acute myeloid leukemia (in vitro). CD33/Siglec-3 can function as a sialic acid-dependent cell adhesion molecule and that binding can be modulated by endogenous sialoglycoconjugates when CD33 is expressed in a plasma membrane.

    CD33/Siglec-3 代替名

    CD33,FLJ00391,gp67,SIGLEC3,SIGLEC-3,P67, [human]
    CD33,Siglec-3,gp67, [mouse]

    CD33/Siglec-3 関連研究

  • Simmons D, et al. (1988) Isolation of a cDNA encoding CD33, a differentiation antigen of myeloid progenitor cells. J Immunol. 141(8): 2797-800.
  • Ulyanova T, et al. (1999) The sialoadhesin CD33 is a myeloid-specific inhibitory receptor. Eur J Immunol. 29(11): 3440-9.
  • Freeman SD, et al. (1995) Characterization of CD33 as a new member of the sialoadhesin family of cellular interaction molecules. Blood. 85(8): 2005-12.
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