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CD32/Fc gamma RII/FCGR2 Protein

発現宿主: Human Cells
  • Slide 1
50030-M08H-50
50030-M08H-100
50 µg / 
100 µg / 
Add to Cart
発現宿主: Human Cells
  • Slide 1
50030-M27H-50
50030-M27H-100
50 µg / 
100 µg / 
Add to Cart
発現宿主: Human Cells
  • Slide 1
  • Slide 1
50030-M27H-B-20
50030-M27H-B-50
20 µg / 
50 µg / 
Add to Cart

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CD32/Fc gamma RII/FCGR2 関連分野

CD32/Fc gamma RII/FCGR2 関連経路

CD32/Fc gamma RII/FCGR2 サマリー & タンパク質情報

CD32/Fc gamma RII/FCGR2 背景

遺伝子の概要: The protein encoded by this gene is a low affinity receptor for the Fc region of immunoglobulin gamma complexes. The encoded protein is involved in the phagocytosis of immune complexes and in the regulation of antibody production by B-cells. Variations in this gene may increase susceptibilty to systemic lupus erythematosus (SLE). Several transcript variants encoding different isoforms have been found for this gene
General information above from NCBI

Receptors for Fc portion of IgG (Fcγ Rs) are members of the Ig superfamily, and are divided into three classes designated Fcγ RI (CD64), Fcγ RII (CD32), and Fcγ RIII (CD16). CD32 protein is a low affinity receptor for IgG that binds only IgG immune complexes and is expressed on a diverse range of cells such as monocytes, macrophages, neutrophils, eosinophils, platelets, and B cells. Human CD32 class is encoded by three closely related genes, and designated Fcγ RII A, B, and C which share 94-99% amino acid identity in their extracellular domains but differ substantially in their transmembrane and cytoplasmic domains. CD32 is involved in a number of immune responses including antibody-dependent cell-mediated cytotoxicity, clearance of immune complexes, release of inflammatory mediators, and regulation of antibody production.

CD32/Fc gamma RII/FCGR2 代替名

CD32/Fc gamma RII/FCGR2 関連研究

  • Williams TE, et al. (2000) Concurrent and independent binding of Fcgamma receptors IIa and IIIb to surface-bound IgG. Biophys J. 79(4): 1867-75.
  • Kanters D, et al. (2007) Expression of activated Fc gamma RII discriminates between multiple granulocyte-priming phenotypes in peripheral blood of allergic asthmatic subjects. J Allergy Clin Immunol. 120(5): 1073-81.
  • Veri MC, et al. (2007) Monoclonal antibodies capable of discriminating the human inhibitory Fcgamma-receptor IIB (CD32B) from the activating Fcgamma-receptor IIA (CD32A): biochemical, biological and functional characterization. Immunology. 121(3): 392-404.
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