CD30 / TNFRSF8 (タンパク質 | 抗体 | cDNA クローン | ELISA キット)

All CD30 / TNFRSF8 reagents are produced in house and quality controlled, including 15 CD30 / TNFRSF8 Antibody, 2 CD30 / TNFRSF8 ELISA, 16 CD30 / TNFRSF8 Gene, 4 CD30 / TNFRSF8 Lysate, 4 CD30 / TNFRSF8 Protein, 1 CD30 / TNFRSF8 qPCR. All CD30 / TNFRSF8 reagents are ready to use.

CD30 / TNFRSF8 Protein (4)

CD30 / TNFRSF8 Antibody (15)

CD30 / TNFRSF8 ELISA キット(すぐに使用できます)& ELISA抗体ペアセット(すぐに使用できません)(2)

CD30 / TNFRSF8 cDNA Clone (16)

NM_001243.3

クローニングベクター cDNA 製品

In lentiviral vector

NM_009401.2

クローニングベクター cDNA 製品

In lentiviral vector

XM_015442579.1

In expression vector

CD30 / TNFRSF8 qPCR Primer (1)

CD30 / TNFRSF8 Lysate (4)

CD30 / TNFRSF8 の背景知識

CD3, also known as TNFRSF8, is a cell membrane protein of the tumor necrosis factor receptor (TNFR) superfamily. CD3 protein is expressed by activated, but not resting, T and B cells. CD3 can regulate proliferation of lymphocytes and may also play an important role in human immunodeficiency virus replication. As a regulator of apoptosis, CD3 protein induces cell death or proliferation, depending on the cell type, and has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity. CD3 protein expression is upregulated in various hematological malignancies, including Reed-Sternberg cells in Hodgkin's disease (HD), anaplastic large cell lymphoma (ALCL) and subsets of Non-Hodgkin's lymphomas (NHLs), and CD3 is also linked to leukocytes in patients with chronic inflammatory diseases, including lupus erythematosus, asthma, rheumatoid arthritis and atopic dermatitis (AD).

CD30 / TNFRSF8 の参考文献

  • Rossi FM, et al. (2001) CD30L up-regulates CD30 and IL-4 expression by T cells. FEBS Lett. 508(3): 418-22.
  • Trovato M, et al. (2001) Expression of CD30 ligand and CD30 receptor in normal thyroid and benign and malignant thyroid nodules. Thyroid. 11(7): 621-8.
  • Ekstrom ES, et al. (2001) Presence of CD30(+) and CD30L(+) cells in human placenta and soluble CD30 levels in cord blood are independent of maternal atopy. Placenta. 22(4): 372-9.
  • Tang C, et al. (2008) A novel role of CD30L/CD30 signaling by T-T cell interaction in Th1 response against mycobacterial infection. J Immunol. 181(9): 6316-27.
  • Sun X, et al. (2008) A critical role of CD30 ligand/CD30 in controlling inflammatory bowel diseases in mice. Gastroenterology. 134(2): 447-58.
  • Oflazoglu E, et al. (2009) Targeting CD30/CD30L in Oncology and Autoimmune and Inflammatory Diseases.Adv Exp Med Biol. 647: 174-85.