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CD30/TNFRSF8  Protein, Antibody, ELISA Kit, cDNA Clone

製品の説明: Active  
発現宿主: Human Cells  
  • Slide 1
10777-H08H-200
10777-H08H-100
200 µg 
100 µg 
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製品の説明: Active  
発現宿主: Human Cells  
  • Slide 1
10777-H03H-200
10777-H03H-100
200 µg 
100 µg 
Add to Cart

CD30/TNFRSF8 Related Area

CD30/TNFRSF8 関連経路

CD30/TNFRSF8 関連製品

CD30/TNFRSF8 サマリー & タンパク質情報

CD30/TNFRSF8 背景

遺伝子の概要: The protein encoded by TNFRSF8 gene is a member of the TNF-receptor superfamily. This receptor is expressed by activated, but not by resting, T and B cells. TRAF2 and TRAF5 can interact with this receptor, and mediate the signal transduction that leads to the activation of NF-kappaB. This receptor is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity. Two alternatively spliced transcript variants of TNFRSF8 gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
General information above from NCBI
サブユニット構造: Interacts with TRAF1, TRAF2, TRAF3 and TRAF5. {ECO:0000269|PubMed:10518213, ECO:0000269|PubMed:8627180, ECO:0000269|PubMed:8999898, ECO:0000269|PubMed:9168896, ECO:0000269|PubMed:9511754}.
細胞内位置: Isoform 1: Cell membrane; Single-pass type I membrane protein.; Isoform 2: Cytoplasm.
翻訳後: Phosphorylated on serine and tyrosine residues.
シーケンスの類似性: Contains 6 TNFR-Cys repeats. {ECO:0000255|PROSITE-ProRule:PRU00206}.
General information above from UniProt

CD30, also known as TNFRSF8, is a cell membrane protein of the tumor necrosis factor receptor (TNFR) superfamily. CD30 protein is expressed by activated, but not resting, T and B cells. CD30 can regulate proliferation of lymphocytes and may also play an important role in human immunodeficiency virus replication. As a regulator of apoptosis, CD30 protein induces cell death or proliferation, depending on the cell type, and has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity. CD30 protein expression is upregulated in various hematological malignancies, including Reed-Sternberg cells in Hodgkin's disease (HD), anaplastic large cell lymphoma (ALCL) and subsets of Non-Hodgkin's lymphomas (NHLs), and CD30 is also linked to leukocytes in patients with chronic inflammatory diseases, including lupus erythematosus, asthma, rheumatoid arthritis and atopic dermatitis (AD).

Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

CD30/TNFRSF8 代替名

CD30,Ki-1,D1S166E, [homo-sapiens]
CD30,D1S166E,Ki-1,TNFRSF8, [human]
Ki,Cd30,D1S166E,Ki-1,RP23-306F22.1,Tnfrsf8, [mouse]
Ki,Cd30,Ki-1,D1S166E, [mus-musculus]

CD30/TNFRSF8 関連研究

  • Rossi FM, et al. (2001) CD30L up-regulates CD30 and IL-4 expression by T cells. FEBS Lett. 508(3): 418-22.
  • Trovato M, et al. (2001) Expression of CD30 ligand and CD30 receptor in normal thyroid and benign and malignant thyroid nodules. Thyroid. 11(7): 621-8.
  • Ekstrom ES, et al. (2001) Presence of CD30(+) and CD30L(+) cells in human placenta and soluble CD30 levels in cord blood are independent of maternal atopy. Placenta. 22(4): 372-9.
  • Tang C, et al. (2008) A novel role of CD30L/CD30 signaling by T-T cell interaction in Th1 response against mycobacterial infection. J Immunol. 181(9): 6316-27.
  • Sun X, et al. (2008) A critical role of CD30 ligand/CD30 in controlling inflammatory bowel diseases in mice. Gastroenterology. 134(2): 447-58.
  • Oflazoglu E, et al. (2009) Targeting CD30/CD30L in Oncology and Autoimmune and Inflammatory Diseases.Adv Exp Med Biol. 647: 174-85.
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